TCF-1 and LEF-1 help launch the TFH program

被引:3
|
作者
Kubo, Masato [1 ,2 ]
机构
[1] Tokyo Univ Sci, Res Inst Biomed Sci, Chiba, Japan
[2] RIKEN, Ctr Integrat Med Sci IMS, Yokohama, Kanagawa, Japan
关键词
CELL DIFFERENTIATION; PATHWAY; FATE;
D O I
10.1038/ni.3254
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Follicular helper T cells (T-FH cells) differentiate from naive T cells, but the picture of this differentiation process remains incomplete. Two studies now identify the related transcriptional regulators TCF-1 and LEF-1 as important early participants in this process.
引用
收藏
页码:900 / 901
页数:2
相关论文
共 50 条
  • [1] TCF-1 and LEF-1 help launch the TFH program
    Masato Kubo
    [J]. Nature Immunology, 2015, 16 : 900 - 901
  • [2] LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6
    Youn Soo Choi
    Jodi A Gullicksrud
    Shaojun Xing
    Zhouhao Zeng
    Qiang Shan
    Fengyin Li
    Paul E Love
    Weiqun Peng
    Hai-Hui Xue
    Shane Crotty
    [J]. Nature Immunology, 2015, 16 : 980 - 990
  • [3] LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor BcI6
    Choi, Youn Soo
    Gullicksrud, Jodi A.
    Xing, Shaojun
    Zeng, Zhouhao
    Shan, Qiang
    Li, Fengyin
    Love, Paul E.
    Peng, Weiqun
    Xue, Hai-Hui
    Crotty, Shane
    [J]. NATURE IMMUNOLOGY, 2015, 16 (09) : 980 - 990
  • [4] New ingredients for brewing CD4+T (cells): TCF-1 and LEF-1
    Jayati Mookerjee-Basu
    Dietmar J Kappes
    [J]. Nature Immunology, 2014, 15 : 593 - 594
  • [5] DIFFERENTIAL EXPRESSION OF THE HMG BOX FACTORS TCF-1 AND LEF-1 DURING MURINE EMBRYOGENESIS
    OOSTERWEGEL, M
    VANDEWETERING, M
    TIMMERMAN, J
    KRUISBEEK, A
    DESTREE, O
    MEIJLINK, F
    CLEVERS, H
    [J]. DEVELOPMENT, 1993, 118 (02): : 439 - 448
  • [6] New ingredients for brewing CD4+ T (cells): TCF-1 and LEF-1
    Mookerjee-Basu, Jayati
    Kappes, Dietmar J.
    [J]. NATURE IMMUNOLOGY, 2014, 15 (07) : 593 - 594
  • [7] Wnt signaling transcription factors TCF-1 and LEF-1 are upregulated in malignant astrocytic brain tumors
    Pecina-Slaus, Nives
    Kafka, Anja
    Tomas, Davor
    Markovic, Leon
    Okstajner, Petar Kresimir
    Sukser, Viktorija
    Kruslin, Bozo
    [J]. HISTOLOGY AND HISTOPATHOLOGY, 2014, 29 (12) : 1557 - 1564
  • [8] Transcription factors TCF-1 and LEF-1 cooperatively regulate the function of intestinal regulatory T cells
    Xie, Z.
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 380 - 380
  • [9] TCF-1 at the Tfh and Th1 Divergence
    Chen, Yaping
    Yu, Di
    [J]. TRENDS IN IMMUNOLOGY, 2015, 36 (12) : 758 - 760
  • [10] A COMMON ANCESTOR OF THE MAMMALIAN TRANSCRIPTION FACTORS TCF-1 AND TCF-1-ALPHA/LEF-1 EXPRESSED IN CHICKEN T-CELLS
    GASTROP, J
    HOEVENAGEL, R
    YOUNG, JR
    CLEVERS, HC
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1992, 22 (05) : 1327 - 1330