LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6

被引：0
|
作者：
Youn Soo Choi
Jodi A Gullicksrud
Shaojun Xing
Zhouhao Zeng
Qiang Shan
Fengyin Li
Paul E Love
Weiqun Peng
Hai-Hui Xue
Shane Crotty
机构：
[1] La Jolla Institute for Allergy and Immunology,Division of Vaccine Discovery
[2] University of Iowa,Department of Microbiology
[3] Interdisciplinary Immunology Graduate Program,Department of Physics
[4] Carver College of Medicine,undefined
[5] University of Iowa,undefined
[6] The George Washington University,undefined
[7] Section on Cellular and Developmental Biology,undefined
[8] NICHD,undefined
[9] NIH,undefined
来源：
Nature Immunology | 2015年 / 16卷
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摘要：
Follicular helper T cells (TFH cells) are specialized effector CD4+ T cells that help B cells develop germinal centers and memory. Crotty and colleagues show that the transcription factors LEF-1 and TCF-1 are required for early TFH differentiation.
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页码：980 / 990
页数：10
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