Fine and bidirectional regulation of toehold-mediated DNA strand displacement by a wedge-like DNA tool

被引：11
|
作者：
Li, Longjie [1 ,2 ]
Zhang, Wenkai [1 ,3 ]
Tang, Xiaofeng [1 ]
Li, Zejian [1 ]
Wu, Yuzhou [2 ]
Xiao, Xianjin [1 ,3 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Inst Reprod Hlth, Wuhan 430030, Peoples R China
[2] Huazhong Univ Sci & Technol, Hubei Key Lab Bioinorgan Chem & Mat Med, Sch Chem & Chem Engn, Wuhan 430074, Peoples R China
[3] Huazhong Univ Sci & Technol, Dept Obstet & Gynaecol, Union Hosp, Tone Med Coll, Wuhan 430022, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 62期
基金：
中国国家自然科学基金;
关键词：
CIRCUITS; SWITCHES; KINETICS;
D O I：
10.1039/d0cc03722b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A wedge-like tool was established to finely and bidirectionally regulate the displacement rate of toehold-mediated strand displacement. This novel tool is very robust in terms of sequence generality and is compatible with most of the current DNA nanodevices based on traditional toehold reactions.
引用
收藏
页码：8794 / 8797
页数：4
相关论文
共 50 条
  • [21] Toehold-Mediated Strand Displacement in Random Sequence Pools
    Mayer, Thomas
    Oesinghaus, Lukas
    Simel, Friedrich C.
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2023, 145 (38) : 21143 - 21143
  • [22] Toehold-Mediated Strand Displacement in Random Sequence Pools
    Mayer, Thomas
    Oesinghaus, Lukas
    Simmel, Friedrich C.
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2023, 145 (01) : 634 - 644
  • [23] Controlling metabolic flux by toehold-mediated strand displacement
    Chen, Rebecca P.
    Hunt, Victoria M.
    Mitkas, Alexander A.
    Siu, Ka-Hei
    Chen, Wilfred
    CURRENT OPINION IN BIOTECHNOLOGY, 2020, 66 : 150 - 157
  • [24] Regulation of DNA strand displacement using a G-quadruplex-mediated toehold
    Feng, Shuo
    Wu, Fan
    Xu, Jiahui
    Chen, Yuqi
    Zhou, Xiang
    RSC ADVANCES, 2014, 4 (98) : 55367 - 55370
  • [25] What Controls the "Off/On Switch" in the Toehold-Mediated Strand Displacement Reaction on DNA Conjugated Gold Nanoparticles?
    Yao, Dongbao
    Wang, Bei
    Xiao, Shiyan
    Song, Tingjie
    Huang, Fujian
    Liang, Haojun
    LANGMUIR, 2015, 31 (25) : 7055 - 7061
  • [26] Toehold-mediated nonenzymatic DNA strand displacement coupling UDG mediated PCR and multi-code magnetic beads for DNA genotyping
    Zhang, Zhang
    Weng, Zhi
    Yao, Juan
    Liu, Dan
    Zhang, Li
    Zhang, Limei
    Xie, Guoming
    MICROCHEMICAL JOURNAL, 2022, 178
  • [27] Predicting DNA toehold-mediated strand displacement rate constants using a DNA-BERT transformer deep learning model
    Akay, Ali
    Reddy, Hemaprakash Nanja
    Galloway, Roma
    Kozyra, Jerzy
    Jackson, Alexander W.
    HELIYON, 2024, 10 (07)
  • [28] Kinetics of Toehold-Mediated DNA Strand Displacement Depend on Fe4IIL4 Tetrahedron Concentration
    Zhu, Jinbo
    Boskovic, Filip
    Nguyen, Bao-Nguyen T.
    Nitschke, Jonathan R.
    Keyser, Ulrich F.
    NANO LETTERS, 2021, 21 (03) : 1368 - 1374
  • [29] Highly selective and sensitive detection of miRNA based on toehold-mediated strand displacement reaction and DNA tetrahedron substrate
    Li, Wei
    Jiang, Wei
    Ding, Yongshun
    Wang, Lei
    BIOSENSORS & BIOELECTRONICS, 2015, 71 : 401 - 406
  • [30] Sequence selective capture, release and analysis of DNA using a magnetic microbead-assisted toehold-mediated DNA strand displacement reaction
    Khodakov, Dmitriy A.
    Khodakova, Anastasia S.
    Linacre, Adrian
    Elli, Amanda V.
    ANALYST, 2014, 139 (14) : 3548 - 3551
12345