The first synthesis of a rotaxane by solid phase chemistry has been achieved, using the resin bead as a 'Mega' stopper during the synthesis. One of the advantages of this methodology over traditional solution routes include the ability to use mass action to drive the chemistry, without complicating the purification process.
机构:
Mem Sloan Kettering Canc Ctr, Lab Bioorgan Chem, New York, NY 10065 USAMem Sloan Kettering Canc Ctr, Lab Bioorgan Chem, New York, NY 10065 USA
Wang, Ting
Danishefsky, Samuel J.
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机构:
Mem Sloan Kettering Canc Ctr, Lab Bioorgan Chem, New York, NY 10065 USA
Columbia Univ, Dept Chem, New York, NY 10027 USAMem Sloan Kettering Canc Ctr, Lab Bioorgan Chem, New York, NY 10065 USA