Template-directed approach to solid-phase combinatorial synthesis of furan-based libraries

被引：29
|
作者：
Gupta, P [1 ]
Singh, SK [1 ]
Pathak, A [1 ]
Kundu, B [1 ]
机构：
[1] Cent Drug Res Inst, Div Med Chem, Lucknow 226001, Uttar Pradesh, India
来源：
TETRAHEDRON | 2002年 / 58卷 / 52期
关键词：
combinatorial chemistry; 5-hydroxymethylfurfural; SPOS;
D O I：
10.1016/S0040-4020(02)01396-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel furan based scaffold 5-hydroxymethylfurfural has been identified for the generation of combinatorial libraries using template directed approach on solid phase. This scaffold has been utilized to afford furan-based bi-heterocyclic structures with extensive chemical diversity using cycloaddition, multicomponent and cyclization reactions. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：10469 / 10474
页数：6
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