Functional characterization of IGF-1R antibodies and possible implications for clinical safety and efficacy

被引:0
|
作者
Kuenkele, Klaus-Peter [1 ]
Hofmann, Marco H. [1 ]
Scheiblich, Stefan [1 ]
Wartha, Katharina [1 ]
Klein, Christian [2 ]
机构
[1] Roche Diagnost GmbH, Penzberg, Germany
[2] Roche Gylcart AG, Schlieren, Switzerland
关键词
D O I
10.1158/1538-7445.AM2011-LB-397
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
LB-397
引用
收藏
页数:2
相关论文
共 50 条
  • [41] IGF-1R EXPRESSION IN LEUKOCYTES OF PATIENTS WITH SPONDYLOARTHRITIS
    Romero-Lopez, N.
    Sanchez-Perez, S.
    Casasola-Vargas, J. C.
    Villasenor-Garcia, A. M.
    Romero-Garcia, H. A.
    Prieto-Chavez, J. L.
    Moreno-Manjon, J.
    Dominguez Lopez, M. L.
    Burgos-Vargas, R.
    Romero-Lopez, J. P.
    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 2024, 42 (09) : 76 - 76
  • [42] Revisiting the IGF-1R as a breast cancer target
    Ekyalongo, Roudy Chiminch
    Yee, Douglas
    NPJ PRECISION ONCOLOGY, 2017, 1
  • [43] CXCL14 Maintains hESC Self-Renewal through Binding to IGF-1R and Activation of the IGF-1R Pathway
    Cheng, Chih-Lun
    Yang, Shang-Chih
    Lai, Chien-Ying
    Wang, Cheng-Kai
    Chang, Ching-Fang
    Lin, Chun-Yu
    Chen, Wei-Ju
    Lin, Po-Yu
    Wu, Han-Chung
    Ma, Nianhan
    Lu, Frank Leigh
    Lu, Jean
    CELLS, 2020, 9 (07) : 1 - 20
  • [44] IGF/IGF-1R signal pathway in pain: a promising therapeutic target
    Ma, Lulin
    Zhao, Wenjing
    Huang, Shiqian
    Xu, Feng
    Wang, Yafeng
    Deng, Daling
    Zhang, Tianhao
    Shu, Shaofang
    Chen, Xiangdong
    INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2023, 19 (11): : 3472 - 3482
  • [45] Precise mapping of an IGF-I-binding site on the IGF-1R
    Keyhanfar, Mehrnaz
    Booker, Grant W.
    Whittaker, Jonathan
    Wallace, John C.
    Forbes, Briony E.
    BIOCHEMICAL JOURNAL, 2007, 401 (01) : 269 - 277
  • [46] Mechanisms of intrinsic and acquired resistance to antibodies targeting IGF-1R in pediatric sarcoma cell lines
    Shackleford, Terry J.
    Hariharan, Seethalakshmi
    Phelps, Doris
    Bid, Hemant
    Zhong, Hiahong
    Houghton, Peter
    CANCER RESEARCH, 2017, 77
  • [47] The role of IGF/IGF-1R signaling in the regulation of cancer stem cells
    Liu, Fengchao
    Ye, Susu
    Zhao, Liu
    Niu, Qinghui
    CLINICAL & TRANSLATIONAL ONCOLOGY, 2024, 26 (12): : 2924 - 2934
  • [48] Dimeric states of transmembrane domains of insulin and IGF-1R receptors: Structures and possible role in activation
    Kuznetsov, Andrey S.
    Zamaletdinov, Miftakh F.
    Bershatsky, Yaroslav, V
    Urban, Anatoly S.
    Bocharova, Olga, V
    Bennasroune, Amar
    Maurice, Pascal
    Bocharov, Eduard, V
    Efremov, Roman G.
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2020, 1862 (11):
  • [49] Identification of an IGF-1R kinase regulatory phosphatase using the fission yeast Schizosaccharomyces pombe and a GFP tagged IGF-1R in mammalian cells
    Buckley, DA
    Loughran, G
    Murphy, G
    Fennelly, C
    O'Connor, R
    JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY, 2002, 55 (01): : 46 - 54
  • [50] Elevated serum concentrations of IGF-1 and IGF-1R in patients with thyroid cancers
    Lawnicka, Hanna
    Motylewska, Ewelina
    Borkowska, Magdalena
    Kuzdak, Krzysztof
    Siejka, Agnieszka
    Swietoslawski, Jacek
    Stepien, Henryk
    Stepien, Tomasz
    BIOMEDICAL PAPERS-OLOMOUC, 2020, 164 (01): : 77 - 83