Functional characterization of IGF-1R antibodies and possible implications for clinical safety and efficacy

被引：0
|
作者：
Kuenkele, Klaus-Peter [1 ]
Hofmann, Marco H. [1 ]
Scheiblich, Stefan [1 ]
Wartha, Katharina [1 ]
Klein, Christian [2 ]
机构：
[1] Roche Diagnost GmbH, Penzberg, Germany
[2] Roche Gylcart AG, Schlieren, Switzerland
来源：
CANCER RESEARCH | 2011年 / 71卷
关键词：
D O I：
10.1158/1538-7445.AM2011-LB-397
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
LB-397
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Functional Comparison of IGF-1R Antibodies and Possible Implications for Clinical Safety and Efficacy
    Kuenkele, K. P.
    Hofmann, M. H.
    Scheiblich, S.
    Wartha, K.
    Rieder, N.
    Klein, C.
    EUROPEAN JOURNAL OF CANCER, 2011, 47 : S157 - S157
  • [2] Gene copy number for EGFR and IGF-1R: Clinical implications
    Hirsch, Fred. R.
    Wynes, Murry W.
    Dziadziuszko, Rafal
    Badzio, Andrzej
    Singh, Shalini
    Franklin, Wilbur A.
    Varella-Garcia, Marileila
    Bunn, Paul A., Jr.
    JOURNAL OF THORACIC ONCOLOGY, 2010, 5 (06) : S218 - S218
  • [3] Novel Mechanisms of Regulation of IGF-1R Action: Functional and Therapeutic Implications
    Worrall, Claire
    Nedelcu, Daniela
    Serly, Julianna
    Suleymanova, Naida
    Oprea, Iulian
    Girnita, Ada
    Girnita, Leonard
    PEDIATRIC ENDOCRINOLOGY REVIEWS PER, 2013, 10 (04) : 473 - 484
  • [4] Investigating Serum and Placental Levels of IGF-1 and IGF-1R in Preeclampsia Patients and Their Clinical Implications
    Su, Junyou
    Huang, Xiaoting
    Meng, Shengping
    Wang, Sumei
    INTERNATIONAL JOURNAL OF WOMENS HEALTH, 2025, 17 : 729 - 738
  • [5] TSHR/IGF-1R Cross-Talk, Not IGF-1R Stimulating Antibodies, Mediates Graves' Ophthalmopathy Pathogenesis
    Krieger, Christine C.
    Neumann, Susanne
    Marcus-Samuels, Bernice
    Gershengorn, Marvin C.
    THYROID, 2017, 27 (05) : 746 - 747
  • [6] Blockade of Peripheral IGF-1R with IGF-1R Antagonist Antibody.
    Kong, M.
    Huffman, D. M.
    Barzilai, N.
    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2010, 58 : 213 - 213
  • [7] IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage
    Tovar, Victoria
    Alsinet, Clara
    Villanueva, Augusto
    Hoshida, Yujin
    Chiang, Derek Y.
    Sole, Manel
    Thung, Swan
    Moyano, Susana
    Toffanin, Sara
    Minguez, Beatriz
    Cabellos, Laia
    Peix, Judit
    Schwartz, Myron
    Mazzaferro, Vincenzo
    Bruix, Jordi
    Llovet, Josep M.
    JOURNAL OF HEPATOLOGY, 2010, 52 (04) : 550 - 559
  • [8] IGF-1R inhibitors
    Paz-Ares, Luis
    JOURNAL OF THORACIC ONCOLOGY, 2009, 4 (09) : S150 - S150
  • [9] A Kinase-Independent Biological Activity for Insulin Growth Factor-1 Receptor (IGF-1R): Implications for Inhibition of the IGF-1R Signal
    Janku, Filip
    Huang, Helen J.
    Angelo, Laura S.
    Kurzrock, Razelle
    ONCOTARGET, 2013, 4 (03) : 463 - 473
  • [10] IGF-1R tyrosine kinase expression and dependency in clones of IGF-1R knockout cells (R-)
    Rosengren, Linda
    Vasilcanu, Daiana
    Vasilcanu, Radu
    Fickenscher, Sandra
    Sehat, Bita
    Natalishvili, Nathalia
    Naughton, Sean
    Yin, Shucheng
    Girnita, Ada
    Girnita, Leonard
    Axelson, Magnus
    Larsson, Olle
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 347 (04) : 1059 - 1066
12345