Lactate Wreaks Havoc on Tumor-Infiltrating T and NK Cells

被引：65

作者：

Scott, Kristen E. N. ^{[1
]}

Cleveland, John L. ^{[1
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Tumor Biol, Tampa, FL 33612 USA

来源：

Cell Metabolism | 2016年 / 24卷 / 05期

关键词：

METABOLISM; ACTIVATION; RESPONSES; ACID;

D O I：

10.1016/j.cmet.2016.10.015

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Both cancer cells and activated T and NK immune cells display enhanced nutrient uptake and metabolism characteristic of the Warburg phenotype. In this issue of Cell Metabolism, Brand et al. (2016) demonstrate that cancer cell LDHA-derived lactic acid selectively disables T and NK cell activation and tumor immune surveillance.

引用

页码：649 / 650

页数：2

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