Lactate Wreaks Havoc on Tumor-Infiltrating T and NK Cells

被引：65

作者：

Scott, Kristen E. N. ^{[1
]}

Cleveland, John L. ^{[1
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Tumor Biol, Tampa, FL 33612 USA

来源：

Cell Metabolism | 2016年 / 24卷 / 05期

关键词：

METABOLISM; ACTIVATION; RESPONSES; ACID;

D O I：

10.1016/j.cmet.2016.10.015

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Both cancer cells and activated T and NK immune cells display enhanced nutrient uptake and metabolism characteristic of the Warburg phenotype. In this issue of Cell Metabolism, Brand et al. (2016) demonstrate that cancer cell LDHA-derived lactic acid selectively disables T and NK cell activation and tumor immune surveillance.

引用

页码：649 / 650

页数：2

共 50 条

[31] Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice
Lu, Tangying
Ramakrishnan, Rupal
Altiok, Soner
Youn, Je-In
Chong, Pingyan
Celis, Esteban
Pisarev, Vladimir
Sherman, Simon
Sporn, Michael B.
Gabrilovich, Dmitry
JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (10): : 4015 - 4029
[32] CD103 is a hallmark of tumor-infiltrating regulatory T cells
Anz, David
Mueller, Wolfgang
Golic, Michaela
Kunz, Wolfgang G.
Rapp, Moritz
Koelzer, Viktor H.
Ellermeier, Jonathan
Ellwart, Joachim W.
Schnurr, Max
Bourquin, Carole
Endres, Stefan
INTERNATIONAL JOURNAL OF CANCER, 2011, 129 (10) : 2417 - 2426
[33] CHARACTERIZATION OF TUMOR-INFILTRATING T CELLS BY HIGHLY MULTIPLEXED IMMUNOFLUORESCENCE IMAGING
Criado-Moronati, E.
Gosselink, A.
Kollet, J.
Dzionek, A.
Heemskerk, B.
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 : A47 - A48
[34] Tumor-infiltrating follicular helper T cells The new kids on the block
Gu-Trantien, Chunyan
Willard-Gallo, Karen
ONCOIMMUNOLOGY, 2013, 2 (10)
[35] Stress response in tumor-infiltrating T cells is linked to immunotherapy resistance
Wang, Linghua
NATURE MEDICINE, 2023, 29 (06) : 1336 - 1337
[36] Hypopigmented mycosis fungoides: An immunological investigation of tumor-infiltrating T cells
Nasu-Tababuchi, Mei
Fujimura, Taku
Kakizaki, Aya
Shido, Kosuke
Hatchome, Naokazu
Kusakari, Yoshiyuki
Aiba, Setsuya
DERMATOLOGICA SINICA, 2016, 34 (02) : 96 - 98
[37] Analysis of tumor-infiltrating gamma delta T cells in rectal cancer
Liang Rong
Ke Li
Rui Li
Hui-Min Liu
Rui Sun
Xiao-Yan Liu
World Journal of Gastroenterology, 2016, 22 (13) : 3573 - 3580
[38] Prognostic Landscape of Tumor-Infiltrating T and B Cells in Human Cancer
Zheng, Ming
Li, Yi-Ming
Liu, Zhen-Yu
Zhang, Xin
Zhou, Yinghui
Jiang, Jian-Li
Zhu, Ping
Yang, Xiang-Min
Tang, Juan
Chen, Zhi-Nan
FRONTIERS IN IMMUNOLOGY, 2022, 12
[39] Distribution and prognostic value of tumor-infiltrating T cells in breast cancer
Meng, Shaoda
Li, Li
Zhou, Meiling
Jiang, Wanjie
Niu, Heng
Yang, Kunxian
MOLECULAR MEDICINE REPORTS, 2018, 18 (05) : 4247 - 4258
[40] Noninvasive detection of tumor-infiltrating T cells by PET reporter imaging
McCracken, Melissa N.
Vatakis, Dimitrios N.
Dixit, Dhaval
McLaughlin, Jami
Zack, Jerome A.
Witte, Owen N.
JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (05): : 1815 - 1826

← 1 2 3 4 5 →