Design and Fabrication of Three-Dimensional Scaffolds for Tissue Engineering of Human Heart Valves

被引：24

作者：

Schaefermeier, P. K. ^{[1
]}

Szymanski, D. ^{[2
]}

Weiss, F. ^{[1
]}

Fu, P. ^{[3
]}

Lueth, T. ^{[4
]}

Schmitz, C. ^{[1
]}

Meiser, B. M. ^{[1
]}

Reichart, B. ^{[1
]}

Sodian, R. ^{[1
]}

机构：

[1] Univ Munich, Dept Cardiac Surg, Lab Tissue Engn, Univ Hosp, DE-81377 Munich, Germany

[2] Charite Univ Med Berlin, Dept Maxillofacial Surg, Surg Robot Lab, D-13353 Berlin, Germany

[3] Deutsch Herzzentrum Berlin, Dept Thorac & Cardiovasc Surg, Lab Tissue Engn, Berlin, Germany

[4] Tech Univ Munich, Zent Inst Med Tech, D-8046 Garching, Germany

来源：

EUROPEAN SURGICAL RESEARCH | 2009年 / 42卷 / 01期

关键词：

Heart valve; Prosthetic heart valve; Aortic valve; Tissue engineering; Polymeric scaffold; Sinus of Valsalva; MODEL;

D O I：

10.1159/000168317

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

We developed a new fabrication technique for 3-dimensional scaffolds for tissue engineering of human heart valve tissue. A human aortic homograft was scanned with an X-ray computer tomograph. The data derived from the X-ray computed tomogram were processed by a computer-aided design program to reconstruct a human heart valve 3-dimensionally. Based on this stereolithographic model, a silicone valve model resembling a human aortic valve was generated. By taking advantage of the thermoplastic properties of polyglycolic acid as scaffold material, we molded a 3-dimensional scaffold for tissue engineering of human heart valves. The valve scaffold showed a deviation of only +/- 3-4% in height, length and inner diameter compared with the homograft. The newly developed technique allows fabricating custom-made, patient-specific polymeric cardiovascular scaffolds for tissue engineering without requiring any suture materials. Copyright (c) 2008 S. Karger AG, Basel

引用

页码：49 / 53

页数：5

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