Design and Fabrication of Three-Dimensional Scaffolds for Tissue Engineering of Human Heart Valves

被引：24
|
作者：
Schaefermeier, P. K. [1 ]
Szymanski, D. [2 ]
Weiss, F. [1 ]
Fu, P. [3 ]
Lueth, T. [4 ]
Schmitz, C. [1 ]
Meiser, B. M. [1 ]
Reichart, B. [1 ]
Sodian, R. [1 ]
机构：
[1] Univ Munich, Dept Cardiac Surg, Lab Tissue Engn, Univ Hosp, DE-81377 Munich, Germany
[2] Charite Univ Med Berlin, Dept Maxillofacial Surg, Surg Robot Lab, D-13353 Berlin, Germany
[3] Deutsch Herzzentrum Berlin, Dept Thorac & Cardiovasc Surg, Lab Tissue Engn, Berlin, Germany
[4] Tech Univ Munich, Zent Inst Med Tech, D-8046 Garching, Germany
来源：
EUROPEAN SURGICAL RESEARCH | 2009年 / 42卷 / 01期
关键词：
Heart valve; Prosthetic heart valve; Aortic valve; Tissue engineering; Polymeric scaffold; Sinus of Valsalva; MODEL;
D O I：
10.1159/000168317
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
We developed a new fabrication technique for 3-dimensional scaffolds for tissue engineering of human heart valve tissue. A human aortic homograft was scanned with an X-ray computer tomograph. The data derived from the X-ray computed tomogram were processed by a computer-aided design program to reconstruct a human heart valve 3-dimensionally. Based on this stereolithographic model, a silicone valve model resembling a human aortic valve was generated. By taking advantage of the thermoplastic properties of polyglycolic acid as scaffold material, we molded a 3-dimensional scaffold for tissue engineering of human heart valves. The valve scaffold showed a deviation of only +/- 3-4% in height, length and inner diameter compared with the homograft. The newly developed technique allows fabricating custom-made, patient-specific polymeric cardiovascular scaffolds for tissue engineering without requiring any suture materials. Copyright (c) 2008 S. Karger AG, Basel
引用
收藏
页码：49 / 53
页数：5
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