Studies on inhibition mechanism of transcription factor NF-κB and DNA binding by chelator pyrogallol red on the basis of its interaction with metal ions

被引：2

作者：

Sharma, R. K. ^{[1
]}

Chelladurai, C. ^{[1
]}

Tiwari, A. D. ^{[1
]}

Rajor, H. K. ^{[1
]}

Mehta, S. ^{[1
]}

Otsuka, M. ^{[2
]}

机构：

[1] Univ Delhi, Dept Chem, Green Chem Network Ctr, Delhi 7, India

[2] Kumamoto Univ, Fac Med & Pharmaceut Sci, Kumamoto 8620973, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2008年 / 16卷 / 19期

关键词：

pyrogallol red; zinc; NF-kappa B-DNA binding; H-1; NMR; IR; TGA and EMSA;

D O I：

10.1016/j.bmc.2008.08.038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies have shown that the zinc influences the DNA binding of transcription factor NF-kappa B. So the zinc-interaction of pyrogallol red (PR) an inhibitor of NF-kappa B-DNA binding was studied by isolating the zinc-PR complex. The complex was characterized using IR, UV-visible, H-1 NMR, and thermal studies. Binding sites of PR were investigated by molecular modeling using MM+ and PM3 methods and by generating molecular electrostatic map. These studies have confirmed the role of metal ion chelation in the inhibition of NF-kappa B-DNA binding by PR. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：9018 / 9022

页数：5

共 44 条

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