MECHANISM OF INTERACTION OF CERTAIN FLAVONOIDS WITH PHOSPHATIDYLCHOLINE OF CELLULAR MEMBRANES

被引：11
|
作者：
Afanas'eva, Yu. G. [1 ]
Fakhretdinova, E. R. [1 ]
Spirikhin, L. V. [1 ]
Nasibullin, R. S. [2 ]
机构：
[1] Bashkir State Med Univ, Ufa, Russia
[2] Russian Acad Sci, Inst Chem, Ufa Sci Ctr, Ufa, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2007年 / 41卷 / 07期
关键词：
Chemical Shift; Flavonoid; Choline; Quercetin; Phosphatidylcholine;
D O I：
10.1007/s11094-007-0080-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Complex formation of cellular phospholipid with 3,5,7,4'-tetrahydroxyflavonol (kaempferol); 3,5,7,3',4'-pentahydroxyflavonol 'quercetin); and 3,5,7,3',4',5'-hexahydroxyflavonol (myricetin) was studied using quantum chemistry and C-13 NMR spectroscopy. It was shown that complexes form through pi-electron systems. Chemical shifts of C-13 nuclei in various rings of the flavonoids and the choline of phosphatidylcholine that were generated through complex formation were determined. It was established that the most probable complex was that where ring C interacts with choline; ring A, simultaneously with the phosphate of phosphatidylcholine.
引用
收藏
页码：354 / 356
页数：3
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