Synthesis and biological evaluation of novel carboxylate phosphabetaines derivatives with long alkyl chains

被引：7

作者：

Galkina, Irina V. ^{[1
]}

Aksunova, Alfiya F. ^{[1
]}

Bakhtiyarov, Dmitriy I. ^{[1
]}

Shulaeva, Marina P. ^{[2
]}

Pozdeev, Oskar K. ^{[2
]}

Egorova, Svetlana N. ^{[2
]}

Bakhtiyarova, Yuliya V. ^{[1
]}

Galkin, Vladimir I. ^{[1
]}

机构：

[1] Kazan Fed Univ, Kazan, Russia

[2] Kazan State Med Univ, Kazan, Russia

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2016年 / 191卷 / 11-12期

关键词：

Phosphabetaines; long alkyl chain; antimicrobial activity; ACIDS; TRIPHENYLPHOSPHINE;

D O I：

10.1080/10426507.2016.1227821

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The purpose of the present study was to investigate the antibacterial activity of novel alkyl esters of carboxylate phosphabetaine: -(carboxyalkyl)ethyltributylphosphonium bromides 4-8. The in vitro microbiological activity of the synthesized phosphonium bromides against gram-positive, gram-negative bacteria and the yeast Candida albicans was determined in comparison to standard agents. Microbiological results indicate the synthesized phosphonium salts possess a broad spectrum of activity against the tested microorganisms. Every newly synthesized compound was characterized by elemental analyses, IR, H-1 NMR, P-31 NMR spectral studies. [GRAPHICS] .

引用

页码：1676 / 1678

页数：3

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