Synthesis and biological evaluation of novel carboxylate phosphabetaines derivatives with long alkyl chains

The purpose of the present study was to investigate the antibacterial activity of novel alkyl esters of carboxylate phosphabetaine: -(carboxyalkyl)ethyltributylphosphonium bromides 4-8. The in vitro microbiological activity of the synthesized phosphonium bromides against gram-positive, gram-negative bacteria and the yeast Candida albicans was determined in comparison to standard agents. Microbiological results indicate the synthesized phosphonium salts possess a broad spectrum of activity against the tested microorganisms. Every newly synthesized compound was characterized by elemental analyses, IR, H-1 NMR, P-31 NMR spectral studies. [GRAPHICS] .