Synthesis and biological evaluation of novel carboxylate phosphabetaines derivatives with long alkyl chains

被引：7
|
作者：
Galkina, Irina V. [1 ]
Aksunova, Alfiya F. [1 ]
Bakhtiyarov, Dmitriy I. [1 ]
Shulaeva, Marina P. [2 ]
Pozdeev, Oskar K. [2 ]
Egorova, Svetlana N. [2 ]
Bakhtiyarova, Yuliya V. [1 ]
Galkin, Vladimir I. [1 ]
机构：
[1] Kazan Fed Univ, Kazan, Russia
[2] Kazan State Med Univ, Kazan, Russia
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2016年 / 191卷 / 11-12期
关键词：
Phosphabetaines; long alkyl chain; antimicrobial activity; ACIDS; TRIPHENYLPHOSPHINE;
D O I：
10.1080/10426507.2016.1227821
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The purpose of the present study was to investigate the antibacterial activity of novel alkyl esters of carboxylate phosphabetaine: -(carboxyalkyl)ethyltributylphosphonium bromides 4-8. The in vitro microbiological activity of the synthesized phosphonium bromides against gram-positive, gram-negative bacteria and the yeast Candida albicans was determined in comparison to standard agents. Microbiological results indicate the synthesized phosphonium salts possess a broad spectrum of activity against the tested microorganisms. Every newly synthesized compound was characterized by elemental analyses, IR, H-1 NMR, P-31 NMR spectral studies. [GRAPHICS] .
引用
收藏
页码：1676 / 1678
页数：3
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