Synthesis of polyfunctionalized acrylates via one-pot reactions of arylamines, methyl propiolate, aromatic aldehydes, and active methylene compounds

被引：13
|
作者：
Sun, Yan [1 ]
Sun, Jing [1 ]
Yan, Chao-Guo [1 ]
机构：
[1] Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Peoples R China
来源：
MOLECULAR DIVERSITY | 2012年 / 16卷 / 01期
基金：
中国国家自然科学基金;
关键词：
One-pot reaction; Cyclization; Multicomponent reaction; beta-enamino ester; Electron-deficient alkyne; MCR; QUINOLINE-DMAD ZWITTERION; DIMETHYL ACETYLENEDICARBOXYLATE; DIALKYL ACETYLENEDICARBOXYLATES; 1,4-DIPOLAR CYCLOADDITION; 4-COMPONENT REACTIONS; EFFICIENT SYNTHESIS; CONSTRUCTION; DERIVATIVES;
D O I：
10.1007/s11030-011-9344-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
An efficient synthetic method for the densely substituted 3-arylaminoacrylates was successfully developed via the one-pot reaction of arylamines, methyl propiolate, aromatic aldehydes, and active methylene compounds such as pivaloylacetonitrile, 1,3-cyclopentanedione, and 4-hydroxycoumarin. The key step of the reaction was believed to involve the formation of a beta-enamino ester and a sequential Michael addition to the in situ formed arylidene dicarbonyl compound.
引用
收藏
页码：163 / 171
页数：9
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