Synthesis of polyfunctionalized acrylates via one-pot reactions of arylamines, methyl propiolate, aromatic aldehydes, and active methylene compounds

被引：13

作者：

Sun, Yan ^{[1
]}

Sun, Jing ^{[1
]}

Yan, Chao-Guo ^{[1
]}

机构：

[1] Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Peoples R China

来源：

MOLECULAR DIVERSITY | 2012年 / 16卷 / 01期

基金：

中国国家自然科学基金;

关键词：

One-pot reaction; Cyclization; Multicomponent reaction; beta-enamino ester; Electron-deficient alkyne; MCR; QUINOLINE-DMAD ZWITTERION; DIMETHYL ACETYLENEDICARBOXYLATE; DIALKYL ACETYLENEDICARBOXYLATES; 1,4-DIPOLAR CYCLOADDITION; 4-COMPONENT REACTIONS; EFFICIENT SYNTHESIS; CONSTRUCTION; DERIVATIVES;

D O I：

10.1007/s11030-011-9344-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An efficient synthetic method for the densely substituted 3-arylaminoacrylates was successfully developed via the one-pot reaction of arylamines, methyl propiolate, aromatic aldehydes, and active methylene compounds such as pivaloylacetonitrile, 1,3-cyclopentanedione, and 4-hydroxycoumarin. The key step of the reaction was believed to involve the formation of a beta-enamino ester and a sequential Michael addition to the in situ formed arylidene dicarbonyl compound.

引用

页码：163 / 171

页数：9

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