Molecular Understanding of the Binding of Macrolide Antibiotics to the Ribosome using Site-Identification via Ligand Competitive Saturation

被引:0
|
作者
Small, Meagan C. [1 ]
Lakkaraju, Sirish Kaushik [1 ]
Raman, E. Prabhu [1 ]
Andrade, Rodrigo B. [2 ]
MacKerell, Alexander D., Jr. [1 ]
机构
[1] Univ Maryland, Dept Pharmaceut Sci, Baltimore, MD 21201 USA
[2] Temple Univ, Dept Chem, Philadelphia, PA 19122 USA
关键词
D O I
10.1016/j.bpj.2014.11.2566
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
2367-Pos
引用
收藏
页码:469A / 469A
页数:1
相关论文
共 50 条
  • [41] Specificity of Molecular Fragments Binding to S100B versus S100A1 as Identified by NMR and Site Identification by Ligand Competitive Saturation (SILCS)
    Young, Brianna D.
    Yu, Wenbo
    Rodriguez, Darex J. Vera
    Varney, Kristen M.
    MacKerell, Alexander D.
    Weber, David J.
    MOLECULES, 2021, 26 (02):
  • [42] Site Identification by Ligand Competitive Saturation (SILCS): Mapping fragment binding sites including consideration of protein flexibility and fragment desolvation using an explicit solvent representation
    MacKerell, Alexander D., Jr.
    Raman, E. Prabhu
    Yu, Wenbo
    Lakkaraju, Sirish Kaushik
    Guvench, Olgun
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
  • [43] ANALYSIS OF THE BINDING-SITE ARCHITECTURE OF MONOCLONAL-ANTIBODIES TO MORPHINE BY USING COMPETITIVE LIGAND-BINDING AND MOLECULAR MODELING
    KUSSIE, PH
    ANCHIN, JM
    SUBRAMANIAM, S
    GLASEL, JA
    LINTHICUM, DS
    JOURNAL OF IMMUNOLOGY, 1991, 146 (12): : 4248 - 4257
  • [44] Excipient-protein interactions for enhancing the stability of protein-based therapeutics using the site identification by ligand competitive saturation technology
    Jo, Sunhwan
    Lakkaraju, Sirish
    Yu, Wenbo
    Mackerell, Alexander
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 256
  • [45] Site Identification by Ligand Competitive Saturation-Biologics Approach for Structure-Based Protein Charge Prediction
    Orr, Asuka A.
    Tao, Aoxiang
    Guvench, Olgun
    MacKerell, Alexander D.
    MOLECULAR PHARMACEUTICS, 2023, 20 (05) : 2600 - 2611
  • [46] Exploring the Interhelical Landscape of the β-2 Adrenergic Receptor to Identify Druggable Intermediate States using Enhanced-Sampling Molecular Dynamics and Site Identification by Ligand Competitive Saturation (SILCS)
    Lind, Christoffer
    Deshpande, Deepak
    MacKerell, Alexander D.
    BIOPHYSICAL JOURNAL, 2019, 116 (03) : 204A - 205A
  • [47] Mapping Functional Group Requirements of Ligands at the Occluded Binding Pocket of β2-Adrenergic G-Protein Coupled Receptor using Site Identification by Ligand Competitive Saturation Simulations
    Lakkaraju, Sirish K.
    Yu, Wenbo
    Raman, Prabhu E.
    MacKerell, Alexander D., Jr.
    BIOPHYSICAL JOURNAL, 2015, 108 (02) : 319A - 319A
  • [48] Excipient-protein interactions for enhancing the stability of protein-based therapeutics using the site identification by ligand competitive saturation (SILCS) technology
    Jo, Sunhwan
    Lakkaraju, Srish
    Yu, Wenbo
    Mackerell, Alexander
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
  • [49] Computational Characterization of Antibody-Excipient Interactions for Rational Excipient Selection Using the Site Identification by Ligand Competitive Saturation-Biologics Approach
    Jo, Sunhwan
    Xu, Amy
    Curtis, Joseph E.
    Somani, Sandeep
    MacKerell, Alexander D., Jr.
    MOLECULAR PHARMACEUTICS, 2020, 17 (11) : 4323 - 4333
  • [50] GalaxySite: ligand-binding-site prediction by using molecular docking
    Heo, Lim
    Shin, Woong-Hee
    Lee, Myeong Sup
    Seok, Chaok
    NUCLEIC ACIDS RESEARCH, 2014, 42 (W1) : W210 - W214