Excipient-protein interactions for enhancing the stability of protein-based therapeutics using the site identification by ligand competitive saturation technology

被引：0
|
作者：
Jo, Sunhwan [1 ]
Lakkaraju, Sirish [1 ]
Yu, Wenbo [2 ]
Mackerell, Alexander [1 ]
机构：
[1] SilcsBio LLC, Baltimore, MD USA
[2] Univ Maryland, Pharm, Baltimore, MD 21201 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2018年 / 256卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
579
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Excipient-protein interactions for enhancing the stability of protein-based therapeutics using the site identification by ligand competitive saturation (SILCS) technology
    Jo, Sunhwan
    Lakkaraju, Srish
    Yu, Wenbo
    Mackerell, Alexander
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
  • [2] Exploring protein-protein interactions using the site-identification by ligand competitive saturation methodology
    Yu, Wenbo
    Jo, Sunhwan
    Lakkaraju, Sirish Kaushik
    Weber, David J.
    MacKerell, Alexander D., Jr.
    PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2019, 87 (04) : 289 - 301
  • [3] Using the site-identification by ligand competitive saturation (SILCS) method to explore protein-protein interactions
    Yu, Wenbo
    Jo, Sunhwan
    Lakkaraju, Sirish
    Mackerell, Alexander
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
  • [4] Exploring protein-protein interactions using the site-identification by ligand competitive saturation (SILCS) method
    Yu, Wenbo
    Mackerell, Alexander
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
  • [5] Optimizing Ligand-Protein Interactions Via Silcs: Site Identification by Ligand Competitive Saturation
    MacKerell, Alexander
    BIOPHYSICAL JOURNAL, 2010, 98 (03) : 755A - 755A
  • [6] Computational Characterization of Antibody-Excipient Interactions for Rational Excipient Selection Using the Site Identification by Ligand Competitive Saturation-Biologics Approach
    Jo, Sunhwan
    Xu, Amy
    Curtis, Joseph E.
    Somani, Sandeep
    MacKerell, Alexander D., Jr.
    MOLECULAR PHARMACEUTICS, 2020, 17 (11) : 4323 - 4333
  • [7] Protein Affinity Pattern Calculations using Protein-Fragment Site Identification by Ligand Competitive Saturation (SILCS)
    Raman, E. Prabhu
    Yu, Wenbo
    MacKerell, Alexander D., Jr.
    BIOPHYSICAL JOURNAL, 2011, 100 (03) : 526 - 526
  • [8] Effects of localized interactions and surface properties on stability of protein-based therapeutics
    Mills, Brittney J.
    Chadwick, Jennifer S. Laurence
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2018, 70 (05) : 609 - 624
  • [9] Estimating Protein-Ligand Relative Binding Affinities using the Site-Identification by Ligand Competitive Saturation Approach
    Goel, Himanshu
    Hazel, Anthony
    Ustach, Vincent D.
    Jo, Sunhwan
    Yu, Wenbo
    MacKerell, Alexander D.
    BIOPHYSICAL JOURNAL, 2021, 120 (03) : 122A - 122A
  • [10] Enhancement of the solubility, stability and bioaccessibility of quercetin using protein-based excipient emulsions
    Chen, Xing
    McClements, David Julian
    Zhu, Yuqing
    Chen, Yan
    Zou, Liqiang
    Liu, Wei
    Cheng, Ce
    Fu, Dongwen
    Liu, Chengmei
    FOOD RESEARCH INTERNATIONAL, 2018, 114 : 30 - 37
12345