Design, Microwave-Assisted Synthesis and in Vitro Antibacterial and Antifungal Activity of 2,5-Disubstituted Benzimidazole

被引：17

作者：

Shi, Yanpeng ^{[1
]}

Jiang, Kai ^{[2
]}

Zheng, Ran ^{[1
]}

Fu, Jiaxu ^{[1
]}

Yan, Liuqing ^{[1
]}

Gu, Qiang ^{[1
]}

Zhang, Yumin ^{[1
]}

Lin, Feng ^{[2
]}

机构：

[1] Jilin Univ, Coll Chem, Changchun 130012, Jilin, Peoples R China

[2] Jilin Univ, Sch Life Sci, Changchun 130012, Jilin, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2019年 / 16卷 / 03期

关键词：

2,5-disubstituted benzimidazole; microwave-assisted synthesis; antimicrobial activity; biological activity; synthesis design; RESISTANT STAPHYLOCOCCUS-EPIDERMIDIS; ANTIMICROBIAL ACTIVITY; CANDIDA-ALBICANS; DERIVATIVES; AUREUS; INHIBITORS; INFECTION; EFFICIENT; THERAPY;

D O I：

10.1002/cbdv.201800510

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seventeen novel 2,5-disubstituted benzimidazole derivatives were designed, synthesized and evaluated for their antibacterial activities. The tested compounds B1-B4 and C2-C6 exhibited not only good antifungal activity but also favorable broad-spectrum antibacterial activity. Also, the lowest MIC of antibacterial and antifungal activity was 2 mu g/mL and 4 mu g/mL, respectively. It suggested that the structure of compound including the different substituent and its sites directly affected the efficacy of the synthesized compounds.

引用

页数：11

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