Design, Microwave-Assisted Synthesis and in Vitro Antibacterial and Antifungal Activity of 2,5-Disubstituted Benzimidazole

被引：17

作者：

Shi, Yanpeng ^{[1
]}

Jiang, Kai ^{[2
]}

Zheng, Ran ^{[1
]}

Fu, Jiaxu ^{[1
]}

Yan, Liuqing ^{[1
]}

Gu, Qiang ^{[1
]}

Zhang, Yumin ^{[1
]}

Lin, Feng ^{[2
]}

机构：

[1] Jilin Univ, Coll Chem, Changchun 130012, Jilin, Peoples R China

[2] Jilin Univ, Sch Life Sci, Changchun 130012, Jilin, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2019年 / 16卷 / 03期

关键词：

2,5-disubstituted benzimidazole; microwave-assisted synthesis; antimicrobial activity; biological activity; synthesis design; RESISTANT STAPHYLOCOCCUS-EPIDERMIDIS; ANTIMICROBIAL ACTIVITY; CANDIDA-ALBICANS; DERIVATIVES; AUREUS; INHIBITORS; INFECTION; EFFICIENT; THERAPY;

D O I：

10.1002/cbdv.201800510

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seventeen novel 2,5-disubstituted benzimidazole derivatives were designed, synthesized and evaluated for their antibacterial activities. The tested compounds B1-B4 and C2-C6 exhibited not only good antifungal activity but also favorable broad-spectrum antibacterial activity. Also, the lowest MIC of antibacterial and antifungal activity was 2 mu g/mL and 4 mu g/mL, respectively. It suggested that the structure of compound including the different substituent and its sites directly affected the efficacy of the synthesized compounds.

引用

页数：11

共 50 条

[31] SYNTHESIS OF TELLUROPHENE AND ITS 2,5-DISUBSTITUTED DERIVATIVES
MACK, W
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1966, 5 (10) : 896 - &
[32] Microwave-Assisted Synthesis of Novel Bisspiropyrrolidine Thiochromanone Derivatives and Antifungal Activity
Wu, Fan
Liang, Guo-Chao
Zhou, Guan
Liu, Quan-Jie
Zhang, Chao-Chao
Yu, Jiao-Jiao
Dong, Xiao-Hui
Song, Ya-Li
LETTERS IN ORGANIC CHEMISTRY, 2016, 13 (03) : 206 - 216
[33] New method for synthesis of 2,5-disubstituted thiophenes
Gubina T.I.
Drevko B.I.
Fedina L.N.
Rogacheva S.M.
Kharchenko V.G.
Chemistry of Heterocyclic Compounds, 1999, 35 (6) : 650 - 652
[34] SYNTHESIS OF 2,7-DISUBSTITUTED PHENANTHRENE AND 2,5-DISUBSTITUTED PHENANTHRENE
BOCHENKOV, VN
ZHURNAL ORGANICHESKOI KHIMII, 1976, 12 (11): : 2430 - 2432
[35] Microwave-assisted synthesis and antifungal activity of novel fused Osthole derivatives
Zhang, Ming-Zhi
Zhang, Rong-Rong
Wang, Jia-Qun
Yu, Xiang
Zhang, Ya-Ling
Wang, Qing-Qing
Zhang, Wei-Hua
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 124 : 10 - 16
[36] POLYMER SUPPORTED SYNTHESIS OF 2,5-DISUBSTITUTED TETRAHYDROFURANS
BEEBE, X
KURTH, MJ
SCHORE, NE
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1992, 203 : 13 - ORGN
[37] Organocatalytic Asymmetric Synthesis of 2,5-Disubstituted Oxazolidines
Mukhopadhyay, Soumendranath
Pan, Subhas Chandra
ADVANCED SYNTHESIS & CATALYSIS, 2019, 361 (05) : 1028 - 1032
[38] New method for synthesis of 2,5-disubstituted thiophenes
Gubina, T.I.
Drevko, B.I.
Fedina, L.N.
Rogacheva, S.M.
Kharchenko, V.G.
Chemistry of Heterocyclic Compounds, 1999, 35 (06): : 650 - 652
[39] New method of 2,5-disubstituted thiophene synthesis
Gubina, TI
Drevko, BI
Fedina, LN
Rogacheva, SM
Kharchenko, VG
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1999, (06): : 736 - 738
[40] A short asymmetric synthesis of 2,5-disubstituted pyrrolidines
Katritzky, AR
Cui, XL
Yang, BZ
Steel, PJ
TETRAHEDRON LETTERS, 1998, 39 (13) : 1697 - 1700

← 1 2 3 4 5 →