Microwave-Assisted Synthesis and Antibacterial Activity of 6-Alkoxy Rheins

被引：0
|
作者：
Zhu, Xiaokang [1 ]
Ye, Xiaoli [2 ]
Yuan, Luejiang [1 ]
Zhu, Jiaying [1 ]
Ding, Yangping [1 ]
Li, Xuegang [1 ]
机构：
[1] Southwest Univ, Sch Pharmaceut Sci, Chongqing 400716, Peoples R China
[2] Southwest Univ, Sch Life Sci, Chongqing 400716, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 30卷 / 09期
关键词：
emodin; 6-alkoxy rhein; microwave; oxidation; antibacterial activity; ANTIMICROBIAL ACTIVITY;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Five new 6-alkoxy rheins have been designed and synthesized through Williamson reaction, acetyl protection, oxidation reaction and deprotection. The effects of microwave and conventional method on the yield of 3-alkyl emodin derivatives were compared. The effects of different oxidants in the synthesis of 3a similar to 3e were studied and the best oxidation conditions were found. All the structures have been confirmed by IR, H-1 NMR, MS and HRMS techniques. The minimal inhibitory concentration (MIC) assay indicated that antibacterial activity changes regularly, as the alkyl chain growth.
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页码：1335 / 1341
页数：7
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