Synthesis and Biological Evaluation of Some New Indolizine Derivatives as Antitumoral Agents

被引：3
|
作者：
Lucescu, Liliana [1 ]
Bicu, Elena [1 ]
Belei, Dalila [1 ]
Dubois, Joelle [2 ]
Ghinet, Alina [1 ,3 ,4 ]
机构：
[1] Alexandru Ioan Cuza Univ, Fac Chem, Dept Organ Chem, B Dul Carol 1,11,Corp A, Iasi 700506, Romania
[2] CNRS, Ctr Rech Gif, Inst Chim Subst Nat, UPR2301, Ave Terrasse, F-91198 Gif Sur Yvette, France
[3] Univ Lille 2, INSERM, LIRIC, U995,CHRU Lille,Fac Med Pole Rech, Pl Verdun, F-59045 Lille, France
[4] HEI, Lab Pharmacochim, Ecole Hautes Etud Ingn HEI, 13 Rue Toul, F-59046 Lille, France
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2016年 / 13卷 / 06期
关键词：
Indolizine; farnesyltransferase; anticancer agent; HUMAN FARNESYLTRANSFERASE; POTENT INHIBITORS; CELL LINE; DISCOVERY; 15-LIPOXYGENASE; CYTOTOXICITY; HETEROCYCLES; ASSAY;
D O I：
10.2174/1570180812666151022221628
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new series of indolizine derivatives were synthesized and screened for the antiproliferative potential against NCI 60 tumor cell line panel. The results of the study revealed a selective and good antitumor growth inhibitory activity against SNB-75 CNS cancer cell line for 1-cyanoindolizine derivative 10b. Moreover, a supplementary in vitro biological evaluation showed that compound 9d exhibited a significant farnesyltransferase inhibition activity (IC50 = 1.07 +/- 0.34 mu M) and could represent a lead for the development of new antitumoral chemical entities.
引用
收藏
页码：479 / 488
页数：10
相关论文
共 50 条
  • [21] Synthesis of some monoselenolipoic acid derivatives and their biological evaluation as anticancer agents
    Xu, Feng
    Yang, Zhen Zhen
    Jiang, Jun Rong
    [J]. JOURNAL OF CHEMICAL RESEARCH, 2013, (05) : 311 - 314
  • [22] Synthesis and biological evaluation of some thiazolidinone derivatives of steroid as antibacterial agents
    Khan, Salman Ahmad
    Yusuf, Mohammed
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (06) : 2597 - 2600
  • [23] Synthesis and biological evaluation of some novel quinoxaline derivatives as anticonvulsant agents
    Elhelby, Abdelghany Aly
    Ayyad, Rezk Rezk
    Zayed, Mohamed Fathalla
    [J]. ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, 2011, 61 (07): : 379 - 381
  • [24] Synthesis and evaluation of pyridinium-hydrazone derivatives as potential antitumoral agents
    Parlar, Sulunay
    Erzurumlu, Yalcin
    Ilhan, Recep
    Kirmizibayrak, Petek Ballar
    Alptuzun, Vildan
    Erciyas, Ercin
    [J]. CHEMICAL BIOLOGY & DRUG DESIGN, 2018, 92 (01) : 1198 - 1205
  • [25] Synthesis, Characterization and Biological Evaluation of Some New Isoxazoline Derivatives
    Jain, Dinesh K.
    Goyal, Neeraj
    Bhadoriya, Upendra
    [J]. ASIAN JOURNAL OF CHEMISTRY, 2013, 25 (02) : 789 - 792
  • [26] Synthesis and Biological Evaluation of Some New Thienopyridine and Thienopyrimidine Derivatives
    El-Saghier, Ahmed M. M.
    Matough, Fathy S.
    Farhat, Mahmoud F.
    Saleh, Nabil A.
    Kreddan, Khaled M.
    El-Tier, Somaia O.
    Bin Hussien, Hind
    [J]. JORDAN JOURNAL OF CHEMISTRY, 2008, 3 (03) : 223 - 232
  • [27] Synthesis, Characterization and Biological Evaluation of Some New Pyrazoline Derivatives
    Jain, Dinesh Kumar
    Bhadoriya, Upendra
    Lodhi, Jawahar Lal
    [J]. ASIAN JOURNAL OF CHEMISTRY, 2013, 25 (03) : 1387 - 1390
  • [28] Synthesis and biological evaluation of some new fused quinazoline derivatives
    Ibrahim, SS
    AbdelHalim, AM
    Gabr, Y
    ElEdfawy, S
    AbdelRahman, RM
    [J]. JOURNAL OF CHEMICAL RESEARCH-S, 1997, (05): : 154 - 155
  • [29] Synthesis of Some New Thiazole Derivatives and Their Biological Activity Evaluation
    Yurttas, Leyla
    Ozkay, Yusuf
    Gencer, Hulya Karaca
    Acar, Ulviye
    [J]. JOURNAL OF CHEMISTRY, 2015, 2015
  • [30] Design, synthesis and biological evaluation of some new 2-Pyrazoline derivatives as potential anticancer agents
    Tok, Fatih
    Abas, Burcin Irem
    Cevik, Ozge
    Kocyigit-Kaymakcioglu, Bedia
    [J]. BIOORGANIC CHEMISTRY, 2020, 102
12345