Synthesis and biological evaluation of some novel quinoxaline derivatives as anticonvulsant agents

In view of their expected anticonvulsant activity, some new derivatives of quinonxaline (V1 - 7) were designed and synthesized by condensation of different aromatic aldehydes with 2-(2-oxo-3-phenylquinoxalin-1(2H)-yl)acetohydrazide (IV). All synthesized compounds were isolated and confirmed by IR, H-1-NMR, MS, elemental analysis and then tested as anticonvulsant agents. Compound V-3 and V-1 showed the highest anticonvulsant effect with anticonvulsant potency relative to phenobarbital sodium of 0.8 and 0.75 whereas compound V-5 exhibited the lowest relative potency of 0.09. The other compounds showed variable activity between these values as follows: V-2 = 0.19, V-4 = 0.41, V-6 = 0.1 and V-7 = 0.15. All compounds showed less activity than the reference compound phenobarbital. But the compounds provided a basis for further optimization.