A polymorphism in DMT1 is associated with lead-related hypertensive status

被引：9
|
作者：
Kim, Hyung-Ki [1 ]
Lee, Hwayoung [1 ,2 ]
Kim, Hak-Jae [1 ,2 ,3 ]
机构：
[1] Soonchunhyang Univ, Coll Med, Dept Clin Pharmacol, Cheonan, South Korea
[2] Soonchunhyang Univ, Coll Med, Soonchunhyang Med Res Inst, Cheonan, South Korea
[3] Kyung Hee Univ, Sch Med, Kowhang Med Res Inst, Seoul, South Korea
来源：
MOLECULAR & CELLULAR TOXICOLOGY | 2013年 / 9卷 / 04期
关键词：
Lead; Hypertension; Divalent metal transporter 1 (DMT1); Polymorphism; NITRIC-OXIDE; BLOOD; EXPOSURE; GENE; CONTRACTION; ABSORPTION; TOXICITY; NRAMP2;
D O I：
10.1007/s13273-013-0051-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Divalent metal transporter 1 (DMT1) is an iron transporting membrane protein important for dietary iron uptake and as a carrier of other metals, such as zinc, copper, and lead. This study evaluated the possible association of DMT1 with clinical variables in a lead-exposed population. We investigated three single nucleotide polymorphisms (SNPs) (1303C/A, 1254T/C and IVS4+44C/A) of DMT1 in 662 male lead-exposed workers from Korea using polymerase chain reaction-restriction fragment length polymorphism. Among the three SNPs, the frequencies of IVS4+44C/A were significantly different between normotensive and hypertensive subjects. This suggests that a polymorphism in DMT1 is associated with increased risk of lead-related hypertensive status in a Korean male population.
引用
收藏
页码：415 / 420
页数：6
相关论文
共 50 条
  • [21] Evaluation of the role of DMT1 polymorphism and Fe, Pb and Cd levels in the blood samples
    Kayaalti, Zeliha
    Soylemezoglu, Tulin
    [J]. TOXICOLOGY LETTERS, 2012, 211 : S66 - S66
  • [22] DMT1 gene polymorphism and blood Pb and Fe levels in Turkish metallurgy workers
    Odabasi, Miyase
    Kayaalti, Zeliha
    Yilmaz, Hinc
    Kurt, Ismail
    Soylemezoglu, Tulin
    [J]. TOXICOLOGY LETTERS, 2012, 211 : S144 - S145
  • [23] Effect of DMT1 knockdown on iron, cadmium, and lead uptake in Caco-2 cells
    Bannon, DI
    Abounader, R
    Lees, PSJ
    Bressler, JP
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2003, 284 (01): : C44 - C50
  • [24] Genetic variations of DMT1 gene and blood iron, lead and cadmium levels in thalassemia patients
    Soylemezoglu, Tulin
    Kayaalti, Zeliha
    Gokyer, Derya Soylemez
    [J]. TOXICOLOGY LETTERS, 2013, 221 : S195 - S195
  • [25] The DMT1 associated protein (DAP) regulates iron uptake by erythroid cells.
    Glass, J
    Chen, Y
    Ma, YX
    Yeh, M
    Yeh, KY
    [J]. BLOOD, 2004, 104 (11) : 19A - 19A
  • [26] Association between blood Pb and Fe levels in Turkish metallurgy workers and a polymorphism of DMT1 gene
    Yaylagul, M.
    Kayaalti, Z.
    Turksoy, V. A.
    Yilmaz, H.
    Kurt, I.
    Soylemezoglu, T.
    [J]. FEBS JOURNAL, 2014, 281 : 548 - 549
  • [27] An association between environmental factors and the IVS4+44C>A polymorphism of the DMT1 gene in age-related macular degeneration
    Daniel Wysokinski
    Malgorzata Zaras
    Mariola Dorecka
    Maja Waszczyk
    Jerzy Szaflik
    Janusz Blasiak
    Jacek P. Szaflik
    [J]. Graefe's Archive for Clinical and Experimental Ophthalmology, 2012, 250 : 1057 - 1065
  • [28] Influence of Iron Supplementation on DMT1(IRE)-induced Transport of Lead by Brain Barrier Systems in vivo
    AN Dai Zhi
    AI Jun Tao
    FANG Hong Juan
    SUN Ru Bao
    SHI Yun
    WANG Li Li
    WANG Qiang
    [J]. Biomedical and Environmental Sciences, 2015, 28 (09) : 651 - 659
  • [29] Influence of Iron Supplementation on DMT1 (IRE)-induced Transport of Lead by Brain Barrier Systems in vivo
    An Dai Zhi
    Ai Jun Tao
    Fang Hong Juan
    Sun Ru Bao
    Shi Yun
    Wang Li Li
    Wang Qiang
    [J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES, 2015, 28 (09) : 651 - 659
  • [30] Effect of DMT1 knockdown on iron, cadmium, and lead uptake in Caco-2 cells.
    Bannon, DI
    Bressler, JP
    Abounader, R
    Lees, PS
    [J]. TOXICOLOGICAL SCIENCES, 2003, 72 : 402 - 402
12345