A polymorphism in DMT1 is associated with lead-related hypertensive status

被引：9

作者：

Kim, Hyung-Ki ^{[1
]}

Lee, Hwayoung ^{[1
,2
]}

Kim, Hak-Jae ^{[1
,2
,3
]}

机构：

[1] Soonchunhyang Univ, Coll Med, Dept Clin Pharmacol, Cheonan, South Korea

[2] Soonchunhyang Univ, Coll Med, Soonchunhyang Med Res Inst, Cheonan, South Korea

[3] Kyung Hee Univ, Sch Med, Kowhang Med Res Inst, Seoul, South Korea

来源：

MOLECULAR & CELLULAR TOXICOLOGY | 2013年 / 9卷 / 04期

关键词：

Lead; Hypertension; Divalent metal transporter 1 (DMT1); Polymorphism; NITRIC-OXIDE; BLOOD; EXPOSURE; GENE; CONTRACTION; ABSORPTION; TOXICITY; NRAMP2;

D O I：

10.1007/s13273-013-0051-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Divalent metal transporter 1 (DMT1) is an iron transporting membrane protein important for dietary iron uptake and as a carrier of other metals, such as zinc, copper, and lead. This study evaluated the possible association of DMT1 with clinical variables in a lead-exposed population. We investigated three single nucleotide polymorphisms (SNPs) (1303C/A, 1254T/C and IVS4+44C/A) of DMT1 in 662 male lead-exposed workers from Korea using polymerase chain reaction-restriction fragment length polymorphism. Among the three SNPs, the frequencies of IVS4+44C/A were significantly different between normotensive and hypertensive subjects. This suggests that a polymorphism in DMT1 is associated with increased risk of lead-related hypertensive status in a Korean male population.

引用

页码：415 / 420

页数：6

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