Bromelain inhibits SARS-CoV-2 infection via targeting ACE-2, TMPRSS2, and spike protein

被引：18

作者：

Sagar, Satish ^{[1
]}

Rathinavel, Ashok Kumar ^{[1
]}

Lutz, William E. ^{[1
]}

Struble, Lucas R. ^{[1
]}

Khurana, Surender ^{[2
]}

Schnaubelt, Andy T. ^{[3
]}

Mishra, Nitish Kumar ^{[4
]}

Guda, Chittibabu ^{[4
,5
]}

Palermo, Nicholas Y. ^{[6
]}

Broadhurst, Mara J. ^{[3
]}

Hoffmann, Tobias ^{[7
]}

Bayles, Kenneth W. ^{[3
]}

Reid, St. Patrick M. ^{[3
]}

Borgstahl, Gloria E. O. ^{[7
]}

Radhakrishnan, Prakash ^{[3
]}

机构：

[1] Univ Nebraska Med Ctr, Eppley Inst Res Canc & Allied Dis, Omaha, NE 68198 USA

[2] US FDA, Ctr Biol Evaluat & Res CBER, Div Viral Prod, Silver Spring, MD USA

[3] Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE 68198 USA

[4] Univ Nebraska Med Ctr, Dept Genet Cell Biol & Anat, Omaha, NE USA

[5] Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE USA

[6] Univ Nebraska Med Ctr, Computat Chem Core, Omaha, NE USA

[7] Robert Koch Inst, Adv Light & Electron Microscopy, Ctr Biol Threats & Special Pathogens 4 ZBS 4, Berlin, Germany

来源：

CLINICAL AND TRANSLATIONAL MEDICINE | 2021年 / 11卷 / 02期

关键词：

D O I：

10.1002/ctm2.281

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页数：6

共 50 条

[41] RNA G-quadruplex in TMPRSS2 reduces SARS-CoV-2 infection
Liu, Geng
Du, Wenya
Sang, Xiongbo
Tong, Qiyu
Wang, Ye
Chen, Guoqing
Yuan, Yi
Jiang, Lili
Cheng, Wei
Liu, Dan
Tian, Yan
Fu, Xianghui
NATURE COMMUNICATIONS, 2022, 13 (01)
[42] Impact of SARS-CoV-2 Spike Mutations on Its Activation by TMPRSS2 and the Alternative TMPRSS13 Protease
Stevaert, Annelies
Van Berwaer, Ria
Mestdagh, Cato
Vandeput, Julie
Vanstreels, Els
Raeymaekers, Valerie
Laporte, Manon
Naesens, Lieve
MBIO, 2022, 13 (04):
[43] Therapeutic Strategies for SARS-CoV-2 acting on ACE-2
Vitiello, A.
Ferrara, F.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021, 156
[44] Expression of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in the Gut of Patients With IBD
Burgueno, Juan F.
Reich, Adrian
Hazime, Hajar
Quintero, Maria A.
Fernandez, Irina
Fritsch, Julia
Santander, Ana M.
Brito, Nivis
Damas, Oriana M.
Deshpande, Amar
Kerman, David H.
Zhang, Lanyu
Gao, Zhen
Ban, Yuguang
Wang, Lily
Pignac-Kobinger, Judith
Abreu, Maria T.
INFLAMMATORY BOWEL DISEASES, 2020, 26 (06) : 797 - 808
[45] Immunocytochemical Assessment of ACE2 and TMPRSS2 in Nasopharyngeal Swabs from SARS-CoV-2 Patients
Pena, Karla Beatriz
Guma, Josep
Guilarte, Carmen
Delamo, Lola
Grifol, Marc
Pique, Berta
Hernandez, Anna
Castene, Helena
Riu, Francesc
Parada, David
FRONTIERS IN BIOSCIENCE-LANDMARK, 2022, 27 (07):
[46] SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2
Lei, Yuyang
Zhang, Jiao
Schiavon, Cara R.
He, Ming
Chen, Lili
Shen, Hui
Zhang, Yichi
Yin, Qian
Cho, Yoshitake
Andrade, Leonardo
Shadel, Gerald S.
Hepokoski, Mark
Lei, Ting
Wang, Hongliang
Zhang, Jin
Yuan, Jason X. -J.
Malhotra, Atul
Manor, Uri
Wang, Shengpeng
Yuan, Zu-Yi
Shyy, John Y-J.
CIRCULATION RESEARCH, 2021, 128 (09) : 1323 - 1326
[47] Expression Pattern of the SARS-CoV-2 Entry Genes ACE2 and TMPRSS2 in the Respiratory Tract
Liu, Yichuan
Qu, Hui-Qi
Qu, Jingchun
Tian, Lifeng
Hakonarson, Hakon
VIRUSES-BASEL, 2020, 12 (10):
[48] EXPRESSION OF THE SARS-COV-2 RECEPTORS ACE2 AND TMPRSS2 IN THE RESPIRATORY TRACT OF CHILDREN AND ADULTS
Nuttall, A. G.
Hedrich, C.
Semple, C.
Losty, P.
Shukla, R.
McPartland, J.
Williams, S.
Northey, S.
McNamara, P.
THORAX, 2021, 76 : A39 - A39
[49] Differential effects of age, sex and dexamethasone therapy on ACE2/TMPRSS2 expression and susceptibility to SARS-CoV-2 infection
Shahbaz, Shima
Oyegbami, Olaide
Saito, Suguru
Osman, Mohammed
Sligl, Wendy
Elahi, Shokrollah
FRONTIERS IN IMMUNOLOGY, 2022, 13
[50] Integrated Bioinformatic Analysis of SARS-CoV-2 Infection Related Genes ACE2, BSG and TMPRSS2 in Aerodigestive Cancers
He, Chaobin
Hua, Xin
Sun, Shuxin
Li, Shaolong
Wang, Jun
Huang, Xin
JOURNAL OF INFLAMMATION RESEARCH, 2021, 14 : 791 - 802

← 1 2 3 4 5 →