Bromelain inhibits SARS-CoV-2 infection via targeting ACE-2, TMPRSS2, and spike protein

被引：18
|
作者：
Sagar, Satish [1 ]
Rathinavel, Ashok Kumar [1 ]
Lutz, William E. [1 ]
Struble, Lucas R. [1 ]
Khurana, Surender [2 ]
Schnaubelt, Andy T. [3 ]
Mishra, Nitish Kumar [4 ]
Guda, Chittibabu [4 ,5 ]
Palermo, Nicholas Y. [6 ]
Broadhurst, Mara J. [3 ]
Hoffmann, Tobias [7 ]
Bayles, Kenneth W. [3 ]
Reid, St. Patrick M. [3 ]
Borgstahl, Gloria E. O. [7 ]
Radhakrishnan, Prakash [3 ]
机构：
[1] Univ Nebraska Med Ctr, Eppley Inst Res Canc & Allied Dis, Omaha, NE 68198 USA
[2] US FDA, Ctr Biol Evaluat & Res CBER, Div Viral Prod, Silver Spring, MD USA
[3] Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE 68198 USA
[4] Univ Nebraska Med Ctr, Dept Genet Cell Biol & Anat, Omaha, NE USA
[5] Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE USA
[6] Univ Nebraska Med Ctr, Computat Chem Core, Omaha, NE USA
[7] Robert Koch Inst, Adv Light & Electron Microscopy, Ctr Biol Threats & Special Pathogens 4 ZBS 4, Berlin, Germany
来源：
CLINICAL AND TRANSLATIONAL MEDICINE | 2021年 / 11卷 / 02期
关键词：
D O I：
10.1002/ctm2.281
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页数：6
相关论文
共 50 条
  • [31] Generation of a lethal mouse model expressing human ACE2 and TMPRSS2 for SARS-CoV-2 infection and pathogenesis
    Jeong, Gi Uk
    Hwang, Insu
    Lee, Wooseong
    Choi, Ji Hyun
    Yoon, Gun Young
    Kim, Hae Soo
    Yang, Jeong-Sun
    Kim, Kyung-Chang
    Lee, Joo-Yeon
    Kim, Seong-Jun
    Kwon, Young-Chan
    Kim, Kyun-Do
    EXPERIMENTAL AND MOLECULAR MEDICINE, 2024, 56 (05): : 1221 - 1229
  • [32] Human mesenchymal stromal cells do not express ACE2 and TMPRSS2 and are not permissive to SARS-CoV-2 infection
    Avanzini, Maria A.
    Mura, Manuela
    Percivalle, Elena
    Bastaroli, Francesca
    Croce, Stefania
    Valsecchi, Chiara
    Lenta, Elisa
    Nykjaer, Giulia
    Cassaniti, Irene
    Bagnarino, Jessica
    Baldanti, Fausto
    Zecca, Marco
    Comoli, Patrizia
    Gnecchi, Massimiliano
    STEM CELLS TRANSLATIONAL MEDICINE, 2021, 10 (04) : 636 - 642
  • [33] The inhibitory effects of toothpaste and mouthwash ingredients on the interaction between the SARS-CoV-2 spike protein and ACE2, and the protease activity of TMPRSS2 in vitro
    Tateyama-Makino, Riho
    Abe-Yutori, Mari
    Iwamoto, Taku
    Tsutsumi, Kota
    Tsuji, Motonori
    Morishita, Satoru
    Kurita, Kei
    Yamamoto, Yukio
    Nishinaga, Eiji
    Tsukinoki, Keiichi
    PLOS ONE, 2021, 16 (09):
  • [34] Hydrogen Sulfide Inhibits TMPRSS2 in Human Airway Epithelial Cells: Implications for SARS-CoV-2 Infection
    Pozzi, Giulia
    Masselli, Elena
    Gobbi, Giuliana
    Mirandola, Prisco
    Taborda-Barata, Luis
    Ampollini, Luca
    Carbognani, Paolo
    Micheloni, Cristina
    Corazza, Francesco
    Galli, Daniela
    Carubbi, Cecilia
    Vitale, Marco
    BIOMEDICINES, 2021, 9 (09)
  • [35] Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection
    Padmanabhan, Pranesh
    Desikan, Rajat
    Dixit, Narendra M.
    PLOS COMPUTATIONAL BIOLOGY, 2020, 16 (12)
  • [36] The Physiological TMPRSS2 Inhibitor HAI-2 Alleviates SARS-CoV-2 Infection
    Tomita, Yuriko
    Matsuyama, Shutoku
    Fukuhara, Hideo
    Maenaka, Katsumi
    Kataoka, Hiroaki
    Hashiguchi, Takao
    Takeda, Makoto
    JOURNAL OF VIROLOGY, 2021, 95 (12)
  • [37] Protein expression of SARS-CoV-2 receptors ACE2 and TMPRSS2 in allergic airways after allergen challenge
    Whetstone, Christiane E.
    Ranjbar, Maral
    Cusack, Ruth P.
    Al-Sajee, Dhuha
    Omer, Hafsa
    Alsaji, Nadia
    Ho, Terence
    MyLinh Duong
    Mitchell, Patrick
    Satia, Imran
    Keith, Paul
    Xie, Yanqing
    MacLean, Jonathan
    Sommer, Doron D.
    O'Byrne, Paul M.
    Sehmi, Roma
    Gauvreau, Gail M.
    ALLERGY, 2023, 78 (11) : 3010 - 3013
  • [38] Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture
    Lukas Wettstein
    Philip Maximilian Knaff
    Christian Kersten
    Patrick Müller
    Tatjana Weil
    Carina Conzelmann
    Janis A Müller
    Maximilian Brückner
    Markus Hoffmann
    Stefan Pöhlmann
    Tanja Schirmeister
    Katharina Landfester
    Jan Münch
    Volker Mailänder
    Communications Biology, 5
  • [39] RNA G-quadruplex in TMPRSS2 reduces SARS-CoV-2 infection
    Geng Liu
    Wenya Du
    Xiongbo Sang
    Qiyu Tong
    Ye Wang
    Guoqing Chen
    Yi Yuan
    Lili Jiang
    Wei Cheng
    Dan Liu
    Yan Tian
    Xianghui Fu
    Nature Communications, 13
  • [40] Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture
    Wettstein, Lukas
    Knaff, Philip Maximilian
    Kersten, Christian
    Mueller, Patrick
    Weil, Tatjana
    Conzelmann, Carina
    Mueller, Janis A.
    Brueckner, Maximilian
    Hoffmann, Markus
    Poehlmann, Stefan
    Schirmeister, Tanja
    Landfester, Katharina
    Muench, Jan
    Mailaender, Volker
    COMMUNICATIONS BIOLOGY, 2022, 5 (01)
12345