Comparison of two different DNA-binding modes of the NF-kappa B p50 homodimer

被引：22
|
作者：
Muller, CW
Rey, FA
Harrison, SC
机构：
[1] HARVARD UNIV,HOWARD HUGHES MED INST,CAMBRIDGE,MA 02138
[2] HARVARD UNIV,DEPT MOLEC & CELLULAR BIOL,CAMBRIDGE,MA 02138
来源：
NATURE STRUCTURAL BIOLOGY | 1996年 / 3卷 / 03期
关键词：
D O I：
10.1038/nsb0396-224
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Analysis of the NF-kappa B p50 homodimer bound to different DNA sequences shows that the protein can recognize half-site spacings of either three or four base pairs. The protein can maintain most of its DNA contacts by a relative reorientation of its two domains.
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页码：224 / 227
页数：4
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