Comparison of two different DNA-binding modes of the NF-kappa B p50 homodimer

被引：22

作者：

Muller, CW

Rey, FA

Harrison, SC

机构：

[1] HARVARD UNIV,HOWARD HUGHES MED INST,CAMBRIDGE,MA 02138

[2] HARVARD UNIV,DEPT MOLEC & CELLULAR BIOL,CAMBRIDGE,MA 02138

来源：

NATURE STRUCTURAL BIOLOGY | 1996年 / 3卷 / 03期

关键词：

D O I：

10.1038/nsb0396-224

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Analysis of the NF-kappa B p50 homodimer bound to different DNA sequences shows that the protein can recognize half-site spacings of either three or four base pairs. The protein can maintain most of its DNA contacts by a relative reorientation of its two domains.

引用

下载

页码：224 / 227

页数：4

共 50 条

[21] NF-kappa B p50 subunit cross-linking to DNA duplexes, containing a monosubstituted pyrophosphate internucleotide bond
Kubareva, EA
Fedorova, OA
Gottikh, MB
Tanaka, H
Malvy, C
Shabarova, ZA
FEBS LETTERS, 1996, 381 (1-2) : 35 - 38
[22] Inhibition of the p50 subunit of NF-kappa B by phosphorothionate-modified antisense oligodeoxynucleotides reduces NF-kappa B expression and immunoglobulin synthesis in murine B cells.
Khaled, A
Soares, L
Butfiloski, E
Stekman, I
Sobel, E
Schiffenbauer, J
FASEB JOURNAL, 1996, 10 (06): : 398 - 398
[23] Engineering of diffraction-quality crystals of the NF-kappa B P52 homodimer:DNA complex
Cramer, P
Muller, CW
FEBS LETTERS, 1997, 405 (03) : 373 - 377
[24] Inhibition of NF-kappa B DNA binding by nitric oxide
Matthews, JR
Botting, CH
Panico, M
Morris, HR
Hay, RT
NUCLEIC ACIDS RESEARCH, 1996, 24 (12) : 2236 - 2242
[25] CYTOPLASMIC RETENTION, DNA-BINDING AND PROCESSING OF THE NF-KAPPA-B P50 PRECURSOR ARE CONTROLLED BY A SMALL REGION IN ITS C-TERMINUS
BLANK, V
KOURILSKY, P
ISRAEL, A
EMBO JOURNAL, 1991, 10 (13): : 4159 - 4167
[26] Characterization of the dimer interface of transcription factor NFκB p50 homodimer
Sengchanthalangsy, LL
Datta, S
Huang, DB
Anderson, E
Braswell, EH
Ghosh, G
JOURNAL OF MOLECULAR BIOLOGY, 1999, 289 (04) : 1029 - 1040
[27] NF-KAPPA-B CONTACTS DNA BY A HETERODIMER OF THE P50 AND P65 SUBUNIT
URBAN, MB
SCHRECK, R
BAEUERLE, PA
EMBO JOURNAL, 1991, 10 (07): : 1817 - 1825
[28] X-ray Crystallographic Study of Preferred Spacing by the NF-κB p50 Homodimer on κB DNA
Zhu, Norman
Mealka, Matthew
Mitchel, Shane
Milani, Christy
Acuna, Lisa M.
Rogers, Eric
Lahana, Ashlee N.
Huxford, Tom
BIOMOLECULES, 2023, 13 (09)
[29] Expression of the p50 and p52 subunits of NF-kappa B transcription factor is required for osteoclast formation, but not survival
Xing, L
Franzoso, G
Siebenlist, U
Boyce, BF
JOURNAL OF BONE AND MINERAL RESEARCH, 1997, 12 (09) : O1 - O1
[30] Redox regulation of NF-kappa B DNA binding activity by dihydrolipoate
Suzuki, YJ
Mizuno, M
Tritschler, HJ
Packer, L
BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, 1995, 36 (02): : 241 - 246

← 1 2 3 4 5 →