Comparison of two different DNA-binding modes of the NF-kappa B p50 homodimer

被引：22

作者：

Muller, CW

Rey, FA

Harrison, SC

机构：

[1] HARVARD UNIV,HOWARD HUGHES MED INST,CAMBRIDGE,MA 02138

[2] HARVARD UNIV,DEPT MOLEC & CELLULAR BIOL,CAMBRIDGE,MA 02138

来源：

NATURE STRUCTURAL BIOLOGY | 1996年 / 3卷 / 03期

关键词：

D O I：

10.1038/nsb0396-224

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Analysis of the NF-kappa B p50 homodimer bound to different DNA sequences shows that the protein can recognize half-site spacings of either three or four base pairs. The protein can maintain most of its DNA contacts by a relative reorientation of its two domains.

引用

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页码：224 / 227

页数：4

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