Hyrtiazepine, an azepino-indole-type alkaloid from the Red Sea marine sponge Hyrtios erectus

被引：64
|
作者：
Sauleau, Pierre
Martin, Marie-Therese
Dau, Marie-Elise Tran Huu
Youssef, Diaa T. A.
Bourguet-Kondracki, Marie-Lise
机构：
[1] CNRS, UMR 5154, MNHN, Lab Chim & Biochim Subst Nat, F-75005 Paris, France
[2] CNRS, ICSN, F-91198 Gif Sur Yvette, France
[3] Suez Canal Univ, Fac Pharm, Dept Pharmacognosy, Ismailia 41522, Egypt
来源：
JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 12期
关键词：
D O I：
10.1021/np060132r
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Biological and chemical investigations of the methanolic crude extract of the Red Sea marine sponge Hyrtios erectus led to the isolation of a novel azepino-indole-type alkaloid named hyrtiazepine (2) and 5-hydroxy-1H-indole-3-carboxylic acid methyl ester (3), together with the known metabolites hyrtiosulawesine (1), 5-hydroxyindole-3-carbaldehyde (4), hyrtiosin A (5), and hyrtiosin B (6). Their structures were elucidated on the basis of mass spectrometry and detailed 2D NMR spectroscopic data. Hyrtiosulawesine (1) displayed a significant antiphospholipase A(2) activity with an IC50 value of 14 mu M in a fluorometric assay using Crotalus adamanteus venom phospholipase A(2).
引用
收藏
页码：1676 / 1679
页数：4
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