Hyrtiazepine, an azepino-indole-type alkaloid from the Red Sea marine sponge Hyrtios erectus

被引：64
|
作者：
Sauleau, Pierre
Martin, Marie-Therese
Dau, Marie-Elise Tran Huu
Youssef, Diaa T. A.
Bourguet-Kondracki, Marie-Lise
机构：
[1] CNRS, UMR 5154, MNHN, Lab Chim & Biochim Subst Nat, F-75005 Paris, France
[2] CNRS, ICSN, F-91198 Gif Sur Yvette, France
[3] Suez Canal Univ, Fac Pharm, Dept Pharmacognosy, Ismailia 41522, Egypt
来源：
JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 12期
关键词：
D O I：
10.1021/np060132r
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Biological and chemical investigations of the methanolic crude extract of the Red Sea marine sponge Hyrtios erectus led to the isolation of a novel azepino-indole-type alkaloid named hyrtiazepine (2) and 5-hydroxy-1H-indole-3-carboxylic acid methyl ester (3), together with the known metabolites hyrtiosulawesine (1), 5-hydroxyindole-3-carbaldehyde (4), hyrtiosin A (5), and hyrtiosin B (6). Their structures were elucidated on the basis of mass spectrometry and detailed 2D NMR spectroscopic data. Hyrtiosulawesine (1) displayed a significant antiphospholipase A(2) activity with an IC50 value of 14 mu M in a fluorometric assay using Crotalus adamanteus venom phospholipase A(2).
引用
收藏
页码：1676 / 1679
页数：4
相关论文
共 50 条
  • [21] Novel neuronal nitric oxide synthase (nNOS) selective inhibitor, aplysinopsin-type indole alkaloid, from marine sponge Hyrtios erecta
    Aoki, S
    Ye, Y
    Higuchi, K
    Takashima, A
    Tanaka, Y
    Kitagawa, I
    Kobayashi, M
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2001, 49 (10) : 1372 - 1374
  • [22] A β-Carboline Alkaloid from the Papua New Guinea Marine Sponge Hyrtios reticulatus
    Inman, Wayne D.
    Bray, Walter M.
    Gassner, Nadine C.
    Lokey, R. Scott
    Tenney, Karen
    Shen, Young Yongchun
    TenDyke, Karen
    Suh, Ted
    Crews, Phillip
    JOURNAL OF NATURAL PRODUCTS, 2010, 73 (02): : 255 - 257
  • [23] Scalarane-based metabolites isolated from the antimitotic extract of the marine sponge Hyrtios erectus
    Diaz-Marrero, Ana R.
    Matainaho, Teatulohi
    van Soest, Rob
    Roberge, Michel
    Andersen, Raymond J.
    NATURAL PRODUCT RESEARCH, 2008, 22 (15) : 1304 - 1309
  • [24] Antioxidant and Anti-Inflammatory Effects of a Methanol Extract from the Marine Sponge Hyrtios erectus
    Muthiyan, Ramachandran
    Mahanta, Nilkamal
    Nambikkairaj, Balwin
    Immanuel, Titus
    De, Arun Kumar
    PHARMACOGNOSY MAGAZINE, 2018, 14 (58) : 534 - 540
  • [25] Various In Vitro Bioactivities of Secondary Metabolites Isolated from the Sponge Hyrtios aff. Erectus from the Red Sea Coast of Egypt
    Nabil-Adam, Asmaa
    Shreadah, Mohamed A.
    Moneam, Nehad M. Abd E. L.
    El-Assar, Samy A.
    TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, 2020, 17 (02) : 127 - 135
  • [26] A new beta-carboline alkaloid isolated from the marine sponge Hyrtios erecta
    BourguetKondracki, ML
    Martin, MT
    Guyot, M
    TETRAHEDRON LETTERS, 1996, 37 (20) : 3457 - 3460
  • [27] HYRTIOSAL, A NEW SESTERTERPENOID WITH A NOVEL CARBON SKELETON FROM THE OKINAWAN MARINE SPONGE HYRTIOS-ERECTUS
    IGUCHI, K
    SHIMADA, Y
    YAMADA, Y
    JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (02): : 522 - 524
  • [28] Hyrtinadine A, a bis-indole alkaloid from a marine sponge
    Endo, Taeko
    Tsuda, Masashi
    Fromont, Jane
    Kobayashi, Jun'ichi
    JOURNAL OF NATURAL PRODUCTS, 2007, 70 (03): : 423 - 424
  • [29] Network Pharmacological Analysis of the Red Sea Sponge Hyrtios erectus Extract to Reveal Anticancer Efficacy of Corresponding Loaded Niosomes
    Abou-Taleb, Heba A.
    Sayed, Ahmed M.
    Refaat, Hesham
    Alsenani, Faisal
    Alaaeldin, Eman
    Mokhtar, Fatma A.
    Abdelmohsen, Usama Ramadan
    Shady, Nourhan Hisham
    MARINE DRUGS, 2022, 20 (10)
  • [30] Salmahyrtisol A, a novel cytotoxic sesterterpene from the Red Sea sponge Hyrtios erecta
    Youssef, DTA
    Yamaki, RK
    Kelly, M
    Scheuer, PJ
    JOURNAL OF NATURAL PRODUCTS, 2002, 65 (01): : 2 - 6
12345