Antimycobacterial scalarane-based sesterterpenes from the red sea sponge Hyrtios erecta

被引：36
|
作者：
Youssef, DTA [1 ]
Shaala, LA
Emara, S
机构：
[1] Suez Canal Univ, Dept Pharmacognosy, Ismailia 41522, Egypt
[2] Suez Canal Univ, Dept Pharmaceut Analyt Chem, Ismailia 41522, Egypt
来源：
JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 12期
关键词：
D O I：
10.1021/np0502645
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new scalarane-type pentacyclic sesterterpene, sesterstatin 7 (1), was isolated from the Red Sea sponge Hyrtios erecta, together with 16-epi-scalarolbutenolide (2), 25-dehydroxy-12-epi-deacetylscalarin (3), 3-acetylsesterstatin 1 (4), and 21-acetoxydeoxyscalarin. The structure of 1 was elucidated by spectroscopic data interpretation. Sesterstatin 7 (1) showed 63% inhibition of Mycobacterium tuberculosis (H(37)Rv) at a concentration of 6.25 mu g/mL. Compound 2 displayed moderate inhibitory activity, while 3 and 4 were weakly active against the same biological target.
引用
收藏
页码：1782 / 1784
页数：3
相关论文
共 50 条
  • [1] Antimycobacterial scalarane-based sesterterpenes from the Red Sea sponge Hyrtios erecta. (vol 68, 1782, 2005)
    Youssef, DTA
    Shaala, LA
    Emara, S
    [J]. JOURNAL OF NATURAL PRODUCTS, 2006, 69 (01): : 172 - 172
  • [2] Cytotoxic scalarane sesterterpenes from a sponge, Hyrtios erecta
    Tsuchiya, N
    Sato, A
    Hata, T
    Sato, N
    Sasagawa, K
    Kobayashi, T
    [J]. JOURNAL OF NATURAL PRODUCTS, 1998, 61 (04): : 468 - 473
  • [3] Antiproliferative Scalarane-Based Metabolites from the Red Sea Sponge Hyrtios erectus
    Elhady, Sameh S.
    Al-Abd, Ahmed M.
    El-Halawany, Ali M.
    Alahdal, Abdulrahman M.
    Hassanean, Hashim A.
    Ahmed, Safwat A.
    [J]. MARINE DRUGS, 2016, 14 (07):
  • [4] Hyrtiosins F and G, two new scalarane sesterterpenes from the South China sea sponge Hyrtios erecta
    Su, Ming-Zhi
    Zhang, Quan
    Yao, Li-Gong
    Wu, Bin
    Guo, Yue-Wei
    [J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2023, 25 (08) : 741 - 747
  • [5] Hyrtiosins A-E, five new scalarane sesterterpenes from the south China sea sponge Hyrtios erecta
    Yu, ZG
    Bi, KS
    Guo, YW
    [J]. HELVETICA CHIMICA ACTA, 2005, 88 (05) : 1004 - 1009
  • [6] Cytotoxic scalarane-type sesterterpenes from the Saudi Red Sea sponge Hyrtios erectus
    Alarif, Walied M.
    Al-Lihaibi, Sultan S.
    Ghandourah, Mohamed A.
    Orif, Mohamed I.
    Basaif, Salim A.
    Ayyad, Seif-Eldin N.
    [J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2016, 18 (06) : 611 - 617
  • [7] Scalarane-based sesterterpenes from an Indonesian sponge Strepsichordaia aliena
    Jiménez, JI
    Yoshida, WY
    Scheuer, PJ
    Kelly, M
    [J]. JOURNAL OF NATURAL PRODUCTS, 2000, 63 (10): : 1388 - 1392
  • [8] New scalarane-based sesterterpenes from the sponge Phyllospongia madagascarensis
    Ponomarenko, LP
    Kalinovsky, AI
    Stonik, VA
    [J]. JOURNAL OF NATURAL PRODUCTS, 2004, 67 (09): : 1507 - 1510
  • [9] Cytotoxic Scalarane Sesterterpenes from the Sponge Hyrtios erectus
    Kwon, Oh-Seok
    Kim, Donghwa
    Kim, Chang-Kwon
    Sun, Jeongyoon
    Sim, Chung J.
    Oh, Dong-Chan
    Lee, Sang Kook
    Oh, Ki-Bong
    Shin, Jongheon
    [J]. MARINE DRUGS, 2020, 18 (05)
  • [10] Scalarane sesterterpenes from the South China Sea sponge Hyrtios erecta and their PTP1B inhibitory activity
    Sun, Li-Li
    Shen, Yi-Ran
    Li, Jia
    Wang, Jian-Rong
    Li, Xu-Wen
    Guo, Yue-Wei
    [J]. TETRAHEDRON, 2023, 137
12345