Cytotoxic scalarane sesterterpenes from a sponge, Hyrtios erecta

被引：23
|
作者：
Tsuchiya, N
Sato, A
Hata, T
Sato, N
Sasagawa, K
Kobayashi, T
机构：
[1] Sankyo Co Ltd, Biomed Res Lab, Tokyo 1400005, Japan
[2] Sankyo Co Ltd, Analyt & Metab Res Labs, Tokyo 1400005, Japan
[3] Sankyo Co Ltd, Pharmacol & Mol Biol Res Labs, Tokyo 1400005, Japan
来源：
JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 04期
关键词：
D O I：
10.1021/np970462z
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Novel scalarane sesterterpenes (1-4) were isolated from a sponge, Hyrtios erecta (order Dictyoceratida). They were characterized by means of spectral analyses, X-ray crystallography, and chemical reactions. Compound 1 showed potent in vitro and in vivo antitumor activities. In addition, the structure-activity relationship was also discussed using computer-assisted structure matching of 1 and aragusterols.
引用
收藏
页码：468 / 473
页数：6
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