Cytotoxic Sesterterpenes from Thai Marine Sponge Hyrtios erectus

被引：8

作者：

Kaweetripob, Wirongrong ^{[1
]}

Mahidol, Chulabhorn ^{[1
,2
]}

Tuntiwachwuttikul, Pittaya ^{[3
]}

Ruchirawat, Somsak ^{[1
,2
,4
]}

Prawat, Hunsa ^{[1
]}

机构：

[1] Chulabhorn Res Inst, Kamphaeng Phet 6 Rd, Bangkok 10210, Thailand

[2] Chulabhorn Royal Acad, Chulabhorn Grad Inst, Chem Biol Program, Kamphaeng Phet 6 Rood, Bangkok 10210, Thailand

[3] Phuket Rajabhat Univ, Fac Sci & Technol, Lab Nat Prod Chem, Phuket 83000, Thailand

[4] Ctr Excellence Environm Hlth & Toxicol EHT, CHE, Minist Educ, Bangkok 10210, Thailand

来源：

MARINE DRUGS | 2018年 / 16卷 / 12期

关键词：

Hyrtios erectus (CRI 572 and CRI 588); Thorectidae; manoalides; scalarane; 2-furanone derivatives; cytotoxic activities; ABSOLUTE-CONFIGURATIONS; COLORIMETRIC ASSAY; INDOLE ALKALOIDS; GROWTH;

D O I：

10.3390/md16120474

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four sesterterpenes, erectusolides B, C, D, and seco-manoalide-25-methyl ether, two 2-furanone derivatives, erectusfuranones A and B, together with thirteen known sesterterpenes, (6Z)-neomanoalide-24-acetate, two diastereomers of 24-O-methylmanoalide, luffariolide B, manoalide, (6E)- and (6Z)-neomanoalide, seco-manoalide, scalarafuran, 12-acetylscalarolide, 12-epi-O-deacetyl-19-deoxyscalarin, 12-epi-scalarin, and 12-O-deacetyl-12-epi-scalarin, three indole alkaloids, 5-hydroxy-1H-indole-3-carbaldehyde, hyrtiosine A, and variabine B, and one norterpene, cavernosine were isolated from the marine sponge Hyrtios erectus. Their structures were determined by means of spectroscopic methods and the absolute configurations of the asymmetric centers were determined using the modified Mosher's method. The cytotoxic activities for the isolated compounds have been reported.

引用

页数：15

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