NEW BROMOINDOLE ALKALOID ISOLATED FROM THE MARINE SPONGE HYRTIOS ERECTUS

被引：4
|
作者：
Bagalagel, Alaa A. [1 ]
Bogari, Hanin A. [1 ]
Ahmed, Safwat A. [2 ]
Diri, Reem M. [1 ]
Elhady, Sameh S. [3 ]
机构：
[1] King Abdulaziz Univ, Fac Pharm, Dept Clin Pharm, Jeddah 21589, Saudi Arabia
[2] Suez Canal Univ, Fac Pharm, Dept Pharmacognosy, Ismailia 41522, Egypt
[3] King Abdulaziz Univ, Fac Pharm, Dept Nat Prod & Alternat Med, Jeddah 21589, Saudi Arabia
来源：
HETEROCYCLES | 2018年 / 96卷 / 04期
关键词：
SMENOSPONGIA SP; INDOLE ALKALOIDS; ANTINEOPLASTIC AGENTS; NATURAL-PRODUCTS; GENUS HYRTIOS; ALTOHYRTIN-A; SESQUITERPENE; METABOLITES; AUREA; SESTERTERPENOIDS;
D O I：
10.3987/COM-18-13869
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
5'- [(6-Bromo-1H-indo1-3-yl)methyl] -3'-methylimidazolidine-2',4'-dione (1), a new bromoindole alkaloid was derived from the marine sponge Hyrtios erectus (order Dictyoceratida) collected in the Red Sea. Additionally, two known indole alkaloids (2-3) were also isolated. The chemical structures of the isolated compounds were elucidated on the basis of detailed spectroscopic analysis as well as comparison with published data. Compound 1 showed weak antiproliferative activity against colorectal carcinoma (HCT-116), breast adenocarcinoma cells (MCF-7) and hepatocellular carcinoma (HepG2). Additionally, at concentration of 3 mg/mL, compound 1 displayed moderate antibacterial activity against S. aureus and E. coli.
引用
收藏
页码：749 / 756
页数：8
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