Biomarker discovery in human cerebrospinal fluid: the need for integrative metabolome and proteome databases

被引：4
|
作者：
Schwarz, Emanuel [1 ]
Torrey, E. Fuller [2 ]
Guest, Paul C. [1 ]
Bahn, Sabine [1 ,3 ]
机构：
[1] Univ Cambridge, Inst Biotechnol, Cambridge CB2 1QT, England
[2] Stanley Med Res Inst, Chevy Chase, MD 20815 USA
[3] Erasmus Univ, Med Ctr, Dept Neurosci, NL-3000 CA Rotterdam, Netherlands
来源：
GENOME MEDICINE | 2012年 / 4卷
关键词：
Schizophrenia; Amyotrophic Lateral Sclerosis; Genome Medicine; Single Platform; Multiplex Immunoassay;
D O I：
10.1186/gm338
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The number of metabolites identified in human cerebrospinal fluid (CSF) has steadily increased over the past 5 years, and in this issue of Genome Medicine David Wishart and colleagues provide a comprehensive update that brings the number of metabolites listed in the CSF metabolome database to 476 compounds. There is now a need for an integrative metabolome-proteome CSF database to maximize the impact of this achievement in biomedical research. Only by such efforts can we hope to unravel the complexity of molecular pathophysiological processes.
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页数：3
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