Four new dammarane-type triterpenes derivatives from hydrolyzate of total Gynostemma pentaphyllum saponins and their bioactivities

被引：11

作者：

Zhang, Xiaoshu ^{[1
,2
]}

Shi, Guohui ^{[1
,2
]}

Liu, Mingbing ^{[1
,2
]}

Chen, Rong ^{[1
,2
]}

Wu, Xiaojun ^{[3
]}

Zhao, Yuqing ^{[1
,2
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Funct Food & Wine, Shenyang, Liaoning, Peoples R China

[2] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang, Liaoning, Peoples R China

[3] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang, Liaoning, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Gynostemma pentaphyllum; anti-hepatic fibrosis; Cardiomyocytes oxidative injury;

D O I：

10.1080/14786419.2018.1428592

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Phytochemical investigation of hydrolysate of total G. pentaphyllum saponins led to the isolation of four novel triterpenes, Gypensapogenin U (1), Gypensapogenin V (2), Gypensapogenin W (3) and Gypensapogenin X (4). The structures of these compounds were identified by 1D, 2D-NMR and HR-ESI-MS evidences. Additionally, the protective activity of these new compounds against cardiomyocytes injury induced by H2O2 and their cytotoxic activity against t-HSC/Cl-6 cells were evaluated. [GRAPHICS] .

引用

页码：1605 / 1611

页数：7

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