Four new dammarane-type triterpenes derivatives from hydrolyzate of total Gynostemma pentaphyllum saponins and their bioactivities

被引：11

作者：

Zhang, Xiaoshu ^{[1
,2
]}

Shi, Guohui ^{[1
,2
]}

Liu, Mingbing ^{[1
,2
]}

Chen, Rong ^{[1
,2
]}

Wu, Xiaojun ^{[3
]}

Zhao, Yuqing ^{[1
,2
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Funct Food & Wine, Shenyang, Liaoning, Peoples R China

[2] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang, Liaoning, Peoples R China

[3] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang, Liaoning, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Gynostemma pentaphyllum; anti-hepatic fibrosis; Cardiomyocytes oxidative injury;

D O I：

10.1080/14786419.2018.1428592

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Phytochemical investigation of hydrolysate of total G. pentaphyllum saponins led to the isolation of four novel triterpenes, Gypensapogenin U (1), Gypensapogenin V (2), Gypensapogenin W (3) and Gypensapogenin X (4). The structures of these compounds were identified by 1D, 2D-NMR and HR-ESI-MS evidences. Additionally, the protective activity of these new compounds against cardiomyocytes injury induced by H2O2 and their cytotoxic activity against t-HSC/Cl-6 cells were evaluated. [GRAPHICS] .

引用

页码：1605 / 1611

页数：7

共 50 条

[31] Cytotoxic dammarane triterpenoids from the hydrolyzate of Gynostemma pentaphyllum
Wang, Jun
Wang, Cheng-Bo
Meng, Xian-Hua
Wang, Wei-Feng
Chai, Tian
Farimani, Mahdi Moridi
Yang, Jun-Li
PHYTOCHEMISTRY LETTERS, 2021, 46 : 136 - 142
[32] Dammarane-type saponins with proprotein convertase subtilisin/kexin type 9 inhibitory activity from Gynostemma pentaphyllum
Huang, Ya-Ping
Wang, Yun-Shan
Liu, Bi-Wen
Song, Zhe
Liang, Xiao-Shuang
Teng, Yuan
Zhang, Jian
Yin, Zhi-Qi
Pan, Ke
PHYTOCHEMISTRY, 2022, 194
[33] New dammarane-type glycosides from Gynostemma pentaphyllum and their lipid-lowering activity
Weng, Xin
Lou, Yun-Yun
Wang, Yun-Shan
Huang, Ya-Ping
Zhang, Jian
Yin, Zhi-Qi
Pan, Ke
BIOORGANIC CHEMISTRY, 2021, 111
[34] STRUCTURE OF A NEW DAMMARANE-TYPE TRITERPENE FROM GYNOSTEMMA-PENTAPHYLLUM (THURB) MAKINO
MACKAY, MF
WEI, JX
CHEN, YG
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1991, 47 : 790 - 793
[35] Protective effects of dammarane-type triterpenes from hydrolyzate of Gynostemma pentaphyllum against H2O2-induced injury and anti-hepatic fibrosis activities
Zhang, Xiaoshu
Shi, Guohui
Liu, Mingbing
Chen, Rong
Wu, Xiaojun
Zhao, Yuqing
PHYTOCHEMISTRY LETTERS, 2018, 25 : 33 - 36
[36] A New Dammarane-type Triterpene with PTP1B Inhibitory Activity from Gynostemma pentaphyllum
Li, Na
Tuo, Zhen-Dong
Xing, Shan-Shan
Qi, Shi-Zhou
Lee, Hyun-Sun
Cui, Long
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2014, 35 (10) : 3122 - 3124
[37] Dammarane-type saponins from heat-processed Gynostemma pentaphyllum show fortified activity against A549 cells
Xiang-Lan Piao
Qian Wu
Jing Yang
Seo Young Park
Dao-Jin Chen
Hui-Min Liu
Archives of Pharmacal Research, 2013, 36 : 874 - 879
[38] Sensory-guided isolation and identification of new sweet-tasting dammarane-type saponins from Jiaogulan (Gynostemma pentaphyllum) herbal tea
Zhang, Hong-Xia
Wang, Zhong-Ze
Du, Zhi-Zhi
FOOD CHEMISTRY, 2022, 388
[39] Dammarane-type saponins from heat-processed Gynostemma pentaphyllum show fortified activity against A549 cells
Piao, Xiang-Lan
Wu, Qian
Yang, Jing
Park, Seo Young
Chen, Dao-Jin
Liu, Hui-Min
ARCHIVES OF PHARMACAL RESEARCH, 2013, 36 (07) : 874 - 879
[40] Profiling and activity screening of Dammarane-type triterpen saponins from Gynostemma pentaphyllum with glucose-dependent insulin secretory activity
Lundqvist, Lena C. E.
Rattigan, Darren
Ehtesham, Emad
Demmou, Camila
Ostenson, Claes-Goran
Sandstrom, Corine
SCIENTIFIC REPORTS, 2019, 9 (1)

← 1 2 3 4 5 →