Four new dammarane-type triterpenes derivatives from hydrolyzate of total Gynostemma pentaphyllum saponins and their bioactivities

被引：11
|
作者：
Zhang, Xiaoshu [1 ,2 ]
Shi, Guohui [1 ,2 ]
Liu, Mingbing [1 ,2 ]
Chen, Rong [1 ,2 ]
Wu, Xiaojun [3 ]
Zhao, Yuqing [1 ,2 ]
机构：
[1] Shenyang Pharmaceut Univ, Sch Funct Food & Wine, Shenyang, Liaoning, Peoples R China
[2] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang, Liaoning, Peoples R China
[3] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang, Liaoning, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 11期
基金：
中国国家自然科学基金;
关键词：
Gynostemma pentaphyllum; anti-hepatic fibrosis; Cardiomyocytes oxidative injury;
D O I：
10.1080/14786419.2018.1428592
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Phytochemical investigation of hydrolysate of total G. pentaphyllum saponins led to the isolation of four novel triterpenes, Gypensapogenin U (1), Gypensapogenin V (2), Gypensapogenin W (3) and Gypensapogenin X (4). The structures of these compounds were identified by 1D, 2D-NMR and HR-ESI-MS evidences. Additionally, the protective activity of these new compounds against cardiomyocytes injury induced by H2O2 and their cytotoxic activity against t-HSC/Cl-6 cells were evaluated. [GRAPHICS] .
引用
收藏
页码：1605 / 1611
页数：7
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