Hedscandines A-C, three undescribed indole alkaloids from Hedyotis scandens with their anti-MRSA activity

被引：4
|
作者：
Wang, Yu-Jun [1 ]
Chen, Xue [1 ]
Yin, Yong [2 ]
Zhou, Wei [1 ]
Zhou, Pei-Fu [3 ]
Zeng, Ling-Gao [4 ]
Hu, Chang-Hua [1 ]
Yin, Guo-Ping [1 ,2 ]
机构：
[1] Southwest Univ, Coll Pharmaceut Sci & Chinese Med, Engn Res Ctr Coptis Dev & Utilizat, Minist Educ, Chongqing 400715, Peoples R China
[2] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 211198, Peoples R China
[3] Guizhou Minzu Univ, Sch Chinese Ethn Med, Key Lab Guizhou Ethn Med Resource Dev & Utilizat, State Ethn Affairs Commiss, Guiyang 550025, Guizhou, Peoples R China
[4] Chongqing Inst Food & Drug Control, NMPA Key Lab Qual Monitoring Narcot Drugs & Psycho, Chongqing 401121, Peoples R China
来源：
PHYTOCHEMISTRY | 2024年 / 219卷
基金：
中国国家自然科学基金;
关键词：
Hedyotis scandens roxb; Rubiaceae; Indole alkaloids; Methicillin-resistant Staphylococcus aureus; Antibacterial activity; Disrupting bacterial membranes;
D O I：
10.1016/j.phytochem.2024.113988
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hedscandines A-C (1-3), three undescribed indole alkaloids were isolated from Hedyotis scandens Roxb, a traditional Chinese medicine widely used in the treatment of respiratory ailments. Their structures were elucidated by extensive spectroscopic data and electronic circular dichroism calculation. Hedscandine A (1), possessed a unique carbon skeleton with a 1,4-oxazonin-2(3H)-one core system and displayed a rapid bactericidal activity against MRSA with a MIC value of 16 mu g/mL. Mechanistic studies showed that compound 1 could disrupt the integrity of bacterial cell membranes and thus lead to bacterial death.
引用
收藏
页数：10
相关论文
共 50 条
  • [41] Anti-malarial activity of indole alkaloids isolated from Aspidosperma olivaceum
    Talita PC Chierrito
    Anna CC Aguiar
    Isabel M de Andrade
    Isabela P Ceravolo
    Regina AC Gonçalves
    Arildo JB de Oliveira
    Antoniana U Krettli
    Malaria Journal, 13
  • [42] Anti-malarial activity of indole alkaloids isolated from Aspidosperma olivaceum
    Chierrito, Talita P. C.
    Aguiar, Anna C. C.
    de Andrade, Isabel M.
    Ceravolo, Isabela P.
    Goncalves, Regina A. C.
    de Oliveira, Arildo J. B.
    Krettli, Antoniana U.
    MALARIA JOURNAL, 2014, 13
  • [43] Catalindoles A-C: brominated indole alkaloids from the starfish Thromidia catalai, which feeds on Theonella sponges
    Matsuta, Ryuga
    Shigeno, Satoru
    Ohshiro, Taichi
    Ueda, Masafumi
    Takada, Kentaro
    FISHERIES SCIENCE, 2024, 90 (05) : 787 - 793
  • [44] Phaeosphaeridiols A-C: Three New Compounds from Undescribed Phaeosphaeriaceae sp. SGSF723
    Si, Lu
    Liu, Yao
    Du, Tingting
    Meng, Wei
    Xu, Lijian
    JOURNAL OF FUNGI, 2022, 8 (11)
  • [45] Riccardin C derivatives as anti-MRSA agents: Structure-activity relationship of a series of hydroxylated bis(bibenzyl)s
    Sawada, Hiromi
    Okazaki, Miki
    Morita, Daichi
    Kuroda, Teruo
    Matsuno, Kenji
    Hashimoto, Yuichi
    Miyachi, Hiroyuki
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (24) : 7444 - 7447
  • [46] Alopecuroidines A-C, three matrine-derived alkaloids from the seeds of Sophora alopecuroides
    Yuan, Xiang
    Li, Zhenyuan
    Feng, Ziming
    Jiang, Jianshuang
    Yang, Yanan
    Zhang, Peicheng
    CHINESE CHEMICAL LETTERS, 2021, 32 (12) : 4058 - 4062
  • [47] Dysidinoid A, an Unusual Meroterpenoid with Anti-MRSA Activity from the South China Sea Sponge Dysidea sp.
    Jiao, Wei-Hua
    Li, Jing
    Liu, Qian
    Xu, Ting-Ting
    Shi, Guo-Hua
    Yu, Hao-Bing
    Yang, Fan
    Han, Bing-Nan
    Li, Min
    Lin, Hou-Wen
    MOLECULES, 2014, 19 (11) : 18025 - 18032
  • [48] Mycopyranone: A 8,8′-binaphthopyranone with potent anti-MRSA activity from the fungus Phialemoniopsis sp.
    Rivera-Chavez, Jose
    Caesar, Lindsay K.
    Garcia-Salazar, Juan J.
    Raja, Huzefa A.
    Cech, Nadja B.
    Pearce, Cedric J.
    Oberlies, Nicholas H.
    TETRAHEDRON LETTERS, 2019, 60 (08) : 594 - 597
  • [49] Promising Anti-MRSA Activity of Brevibacillus sp. Isolated from Soil and Strain Improvement by UV Mutagenesis
    Songnaka, Nuttapon
    Lertcanawanichakul, Monthon
    Atipairin, Apichart
    SCIENTIA PHARMACEUTICA, 2021, 89 (01) : 1 - 16
  • [50] Synthesis and structure-activity relationship of C-3 quaternary ammonium cephalosporins exhibiting anti-MRSA activities
    Kim, OK
    Hudyma, TW
    Matiskella, JD
    Ueda, Y
    Bronson, JJ
    Mansuri, MM
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (21) : 2753 - 2758
12345