Hedscandines A-C, three undescribed indole alkaloids from Hedyotis scandens with their anti-MRSA activity

被引：4
|
作者：
Wang, Yu-Jun [1 ]
Chen, Xue [1 ]
Yin, Yong [2 ]
Zhou, Wei [1 ]
Zhou, Pei-Fu [3 ]
Zeng, Ling-Gao [4 ]
Hu, Chang-Hua [1 ]
Yin, Guo-Ping [1 ,2 ]
机构：
[1] Southwest Univ, Coll Pharmaceut Sci & Chinese Med, Engn Res Ctr Coptis Dev & Utilizat, Minist Educ, Chongqing 400715, Peoples R China
[2] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 211198, Peoples R China
[3] Guizhou Minzu Univ, Sch Chinese Ethn Med, Key Lab Guizhou Ethn Med Resource Dev & Utilizat, State Ethn Affairs Commiss, Guiyang 550025, Guizhou, Peoples R China
[4] Chongqing Inst Food & Drug Control, NMPA Key Lab Qual Monitoring Narcot Drugs & Psycho, Chongqing 401121, Peoples R China
来源：
PHYTOCHEMISTRY | 2024年 / 219卷
基金：
中国国家自然科学基金;
关键词：
Hedyotis scandens roxb; Rubiaceae; Indole alkaloids; Methicillin-resistant Staphylococcus aureus; Antibacterial activity; Disrupting bacterial membranes;
D O I：
10.1016/j.phytochem.2024.113988
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hedscandines A-C (1-3), three undescribed indole alkaloids were isolated from Hedyotis scandens Roxb, a traditional Chinese medicine widely used in the treatment of respiratory ailments. Their structures were elucidated by extensive spectroscopic data and electronic circular dichroism calculation. Hedscandine A (1), possessed a unique carbon skeleton with a 1,4-oxazonin-2(3H)-one core system and displayed a rapid bactericidal activity against MRSA with a MIC value of 16 mu g/mL. Mechanistic studies showed that compound 1 could disrupt the integrity of bacterial cell membranes and thus lead to bacterial death.
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页数：10
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