Synthesis and structure-activity relationship of C-3 quaternary ammonium cephalosporins exhibiting anti-MRSA activities

被引：13
|
作者：
Kim, OK
Hudyma, TW
Matiskella, JD
Ueda, Y
Bronson, JJ
Mansuri, MM
机构：
[1] Antiinfective Chemistry, Bristol-Myers Squibb P.R.I., Wallingford
[2] Mitotix, Inc., Cambridge
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 21期
关键词：
D O I：
10.1016/S0960-894X(97)10078-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of cephalosporins bearing C-3 quaternary ammonium groups were prepared and evaluated for their anti-MRSA activity. They exhibit good to excellent in vitro activity (MICs = 1-8 mu g/mL) against MRSA. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：2753 / 2758
页数：6
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