Application of the Mannich reaction in the structural modification of natural products

被引：9
|
作者：
Pu, Miao-Xia [1 ]
Guo, Hong-Yan [2 ]
Quan, Zhe-Shan [2 ]
Li, Xiaoting [2 ]
Shen, Qing-Kun [2 ]
机构：
[1] Yanbian Univ, Coll Integrat Sci, Interdisciplinary Program Biol Funct Mol, Yanji, Peoples R China
[2] Yanbian Univ, Coll Pharm, Key Lab Nat Med Changbai Mt, Minist Educ, Yanji, Peoples R China
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2023年 / 38卷 / 01期
关键词：
Natural products; Mannich reaction; biological activity; BIOLOGICAL EVALUATION; BASE DERIVATIVES; MAGNOLIA-OBOVATA; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ANTICANCER ACTIVITY; CELL-PROLIFERATION; DUAL INHIBITORS; IN-VIVO; DESIGN;
D O I：
10.1080/14756366.2023.2235095
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Mannich reaction is commonly used to introduce N atoms into compound molecules and is thus widely applied in drug synthesis. The Mannich reaction accounts for a certain proportion of structural modifications of natural products. The introduction of Mannich bases can significantly improve the activity, hydrophilicity, and medicinal properties of compounds; therefore, the Mannich reaction is widely used for the structural modification of natural products. In this paper, the application of the Mannich reaction to the structural modification of natural products is reviewed, providing a method for the structural modification of natural products.
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收藏
页数：18
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