Application of the Mannich reaction in the structural modification of natural products

被引：9

作者：

Pu, Miao-Xia ^{[1
]}

Guo, Hong-Yan ^{[2
]}

Quan, Zhe-Shan ^{[2
]}

Li, Xiaoting ^{[2
]}

Shen, Qing-Kun ^{[2
]}

机构：

[1] Yanbian Univ, Coll Integrat Sci, Interdisciplinary Program Biol Funct Mol, Yanji, Peoples R China

[2] Yanbian Univ, Coll Pharm, Key Lab Nat Med Changbai Mt, Minist Educ, Yanji, Peoples R China

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2023年 / 38卷 / 01期

关键词：

Natural products; Mannich reaction; biological activity; BIOLOGICAL EVALUATION; BASE DERIVATIVES; MAGNOLIA-OBOVATA; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ANTICANCER ACTIVITY; CELL-PROLIFERATION; DUAL INHIBITORS; IN-VIVO; DESIGN;

D O I：

10.1080/14756366.2023.2235095

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Mannich reaction is commonly used to introduce N atoms into compound molecules and is thus widely applied in drug synthesis. The Mannich reaction accounts for a certain proportion of structural modifications of natural products. The introduction of Mannich bases can significantly improve the activity, hydrophilicity, and medicinal properties of compounds; therefore, the Mannich reaction is widely used for the structural modification of natural products. In this paper, the application of the Mannich reaction to the structural modification of natural products is reviewed, providing a method for the structural modification of natural products.

引用

页数：18

共 50 条

[21] Latest Progress and Application of Mannich Reaction
Liu, Yuting
Wu, Qianqian
Yin, Dawei
Li, Diyang
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2016, 36 (05) : 927 - 938
[22] Application of the DFT Methods in Structural Elucidation of Natural Products
Hashimoto, Masaru
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 2018, 76 (08) : 842 - 850
[23] MODIFICATION OF POLONOVSKI REACTION - PREPARATION OF A NEW MANNICH REAGENT
AHOND, A
CAVE, A
KANFAN, C
POTIER, P
BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE, 1970, (07): : 2707 - &
[24] Modification of lignin by Mannich type reaction for production of flocculants
Slacke, MP
Riedl, B
Stevanovic-Janezic, T
ADVANCES IN LIGNOCELLULOSICS CHEMISTRY FOR ECOLOGICALLY FRIENDLY PULPING AND BLEACHING TECHNOLOGIES, 1998, : 325 - 328
[25] Spirocyclic Orthoesters, Orthothioesters and Orthoaminals in the Synthesis and Structural Modification of Natural Products
Undheim, Kjell
SYNTHESIS-STUTTGART, 2017, 49 (04): : 705 - 723
[26] Natural products as leads in structural modification studies yielding new agrochemicals
Miyakado, M
Watanabe, K
Miyamoto, J
PHYTOCHEMICALS FOR PEST CONTROL, 1997, 658 : 168 - 182
[27] Insights into drug discovery from natural products through structural modification
Chen, Jichao
Li, Wenlong
Yao, Hequan
Xu, Jinyi
FITOTERAPIA, 2015, 103 : 231 - 241
[28] Natural Products as Leads in Structural Modification Studies Yielding New Agrochemicals
Agric. Chemicals Research Laboratory, Sumitomo Chemical Company, Ltd., 4-2-1 Takatsukasa, Takarazuka, Hyogo 665, Japan
不详
ACS Symp Ser, (167-182):
[29] Natural Products as Leads in Structural Modification Studies Yielding New Agrochemicals
Miyakado, M.
Watanabe, K.
Miyamoto, J.
ACS Symposium Series, (658):
[30] Application of Structural Concepts to Evaluate the Potential Carcinogenicity of Natural Products
Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh
PA
15238, United States
不详
OH
44106, United States
SAR QSAR Environ. Res., 2 (79-98):

← 1 2 3 4 5 →