Gaussian-process-based Bayesian optimization for neurostimulation interventions in rats

被引:3
|
作者
Choiniere, Leo [1 ,2 ,5 ]
Guay-Hottin, Rose [1 ,2 ,3 ,4 ,5 ]
Picard, Remi [1 ,2 ,3 ,4 ]
Lajoie, Guillaume [5 ,6 ]
Bonizzato, Marco [1 ,2 ,3 ,4 ,5 ]
Dancause, Numa [1 ,2 ]
机构
[1] Univ Montreal, Dept Neurosci, Montreal, PQ H3T 1J4, Canada
[2] Univ Montreal, Ctr Interdisciplinaire Rech Cerveau & Apprentissag, Montreal, PQ H3T 1J4, Canada
[3] Polytech Montreal, Dept Elect Engn, Montreal, PQ H3T 1J4, Canada
[4] Polytech Montreal, Inst Biomed Engn, Montreal, PQ H3T 1J4, Canada
[5] Mila Quebec Inst, Montreal, PQ H2S 3H1, Canada
[6] Univ Montreal, Math & Stat Dept, Montreal, PQ H3T 1J4, Canada
来源
STAR PROTOCOLS | 2024年 / 5卷 / 01期
基金
加拿大自然科学与工程研究理事会;
关键词
PRIMARY MOTOR CORTEX; MICROSTIMULATION; ORGANIZATION;
D O I
10.1016/j.xpro.2024.102885
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Effective neural stimulation requires adequate parametrization. Gaussian -process (GP) -based Bayesian optimization (BO) offers a framework to discover optimal stimulation parameters in real time. Here, we first provide a general protocol to deploy this framework in neurostimulation interventions and follow by exemplifying its use in detail. Specifically, we describe the steps to implant rats with multi -channel electrode arrays in the hindlimb motor cortex. We then detail how to utilize the GP -BO algorithm to maximize evoked target movements, measured as electromyographic responses. For complete details on the use and execution of this protocol, please refer to Bonizzato and colleagues (2023).1
引用
收藏
页数:29
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