HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation

被引：3
|
作者：
Jensen, Bjorn-Erik Ole [1 ,2 ]
Kobbe, Guido [1 ,2 ]
机构：
[1] Univ Hosp Dusseldorf, German, Dusseldorf, Germany
[2] Heinrich Heine Univ, German, Dusseldorf, Germany
来源：
NATURE MEDICINE | 2023年 / 29卷 / 3期
关键词：
D O I：
10.1038/s41591-023-02215-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We describe a 53-year-old man with HIV-1 who received allogeneic CCR5 Delta 32/Delta 32 hematopoietic stem cell transplantation (HSCT) in 2013 to treat acute myeloid leukemia. Four years after analytic treatment interruption (ATI), the absence of viral rebound and the lack of immunological correlates of HIV-1 antigen persistence provide convincing evidence for HIV-1 cure.
引用
收藏
页码：547 / 548
页数：2
相关论文
共 50 条
  • [31] EBV reactivation after allogeneic hematopoietic stem cell transplantation is associated with expression and polymorphism of the CCR5 gene
    Bogunia-Kubik, K.
    Jaskula, E.
    Sokolowska, D.
    Kuzyk, A.
    Lange, A.
    TISSUE ANTIGENS, 2006, 67 (06): : 479 - 479
  • [32] More on Shift of HIV Tropism in Stem-Cell Transplantation with CCR5 Delta32/Delta32 Mutation REPLY
    Verheyen, Jens
    Esser, Stefan
    Kordelas, Lambros
    NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (25): : 2438 - 2438
  • [33] High frequency of the HIV-1 protective CCR5 Δ32 deletion in native Estonians
    Kalev, I
    Mikelsaar, AV
    Beckman, L
    Tasa, G
    Pärlist, P
    EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2000, 16 (12) : 1107 - 1109
  • [34] High frequency of the HIV-1 protective CCR5 Δ32 deletion in native Estonians
    I. Kalev
    A.-V. Mikelsaar
    L. Beckman
    G. Tasa
    P. Pärlist
    European Journal of Epidemiology, 2000, 16 : 1107 - 1109
  • [35] The global distribution of CCR5 delta 32 polymorphism: role in HIV-1 protection
    Anuroopa Gupta
    Harish Padh
    BMC Infectious Diseases, 12 (Suppl 1)
  • [36] Elimination of HIV in a patient with AML after allogeneic blood stem cell transplantation from a CCR5-d32 donor
    Kobbe, G.
    Knops, E.
    Luebke, N.
    Kaiser, R.
    Nachtkamp, K.
    Dunay, G. A.
    Kobbe, R.
    Fischer, J. C.
    Huettig, F.
    Haas, R.
    Haeussinger, D.
    Jensen, B. E. O.
    BONE MARROW TRANSPLANTATION, 2016, 51 : S268 - S269
  • [37] Treatment of HIV and acute myeloid leukemia by allogeneic CCR5-d32 blood stem cell transplantation
    Knops, E.
    Kobbe, G.
    Kaiser, R.
    Luebke, N.
    Dunay, G.
    Fischer, J.
    Huettig, F.
    Wensing, A.
    Haas, R.
    Nijhuis, M.
    Martinez-Picado, J.
    Haeussinger, D.
    Jensen, B.
    JOURNAL OF CLINICAL VIROLOGY, 2016, 82 : S86 - S86
  • [38] Treatment of HIV and acute myeloid leukaemia by allogeneic CCR5-d32 blood stem cell transplantation
    Knops, Elena
    Kobbe, Guido
    Kaiser, Rolf
    Luebke, Nadine
    Dunay, Gabor
    Wensing, Annemarie
    Martinez-Picado, Javier
    Nijhuis, Monique
    Fischer, Johannes
    Huettig, Falk
    Haas, Rainer
    Haeussinger, Dieter
    Jensen, Bjoern
    JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 2016, 19
  • [39] Polymorphisms in CCR5Δ32 and Risk of HIV-1 Infection in the Southeast of Caspian Sea, Iran
    Heydarifard, Zahra
    Tabarraei, Alijan
    Moradi, Abdolvahab
    DISEASE MARKERS, 2017, 2017
  • [40] Distribution of CCR5 Δ32 HIV-1 resistance allele frequency at Zanjan province in Iran
    Farshbaf, Alieh
    Biglari, Alireza
    Faghihzadeh, Soghrat
    Esmaeilzadeh, Abdolreza
    IMMUNOPATHOLOGIA PERSA, 2021, 7 (02):
12345