HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation

被引：3
|
作者：
Jensen, Bjorn-Erik Ole [1 ,2 ]
Kobbe, Guido [1 ,2 ]
机构：
[1] Univ Hosp Dusseldorf, German, Dusseldorf, Germany
[2] Heinrich Heine Univ, German, Dusseldorf, Germany
来源：
NATURE MEDICINE | 2023年 / 29卷 / 3期
关键词：
D O I：
10.1038/s41591-023-02215-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We describe a 53-year-old man with HIV-1 who received allogeneic CCR5 Delta 32/Delta 32 hematopoietic stem cell transplantation (HSCT) in 2013 to treat acute myeloid leukemia. Four years after analytic treatment interruption (ATI), the absence of viral rebound and the lack of immunological correlates of HIV-1 antigen persistence provide convincing evidence for HIV-1 cure.
引用
收藏
页码：547 / 548
页数：2
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